Target Validation Information
TTD ID	T16514
Target Name	Fatty acid synthase (FASN)
Type of Target	Successful
Drug Potency against Target	Cerulenin	Drug Info	IC50 = 1 mol	[4]
	(-)-CATECHINGALLATE	Drug Info	Ki = 2800 nM	[1]
	2-Hexadecynoic acid	Drug Info	Ki = 4800 nM	[3]
	3,7,3',4'-TETRAHYDROXYFLAVONE	Drug Info	IC50 = 2000 nM	[1]
	4-hydroxy-6-nitro-3-phenylquinolin-2(1H)-one	Drug Info	IC50 = 550 nM	[2]
	4-hydroxy-8-nitro-3-phenylquinolin-2(1H)-one	Drug Info	IC50 = 3000 nM	[2]
	biochanin A	Drug Info	IC50 = 8000 nM	[1]
	Epigallocatechin gallate	Drug Info	IC50 = 400 nM	[1]
	GALLOCATECHIN GALLATE	Drug Info	IC50 = 600 nM	[1]
	MORIN	Drug Info	IC50 = 8000 nM	[1]
References
REF 1	Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53.
REF 2	3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4620-3.
REF 3	2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorg Med Chem. 2010 Nov 1;18(21):7475-85.
REF 4	Binding site of cerulenin in fatty acid synthetase. J Biochem. 1989 May;105(5):751-5.

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