| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T12817 | ||||
| Target Name | Lipopolysaccharide-associated protein 1 (HSPA8) | ||||
| Type of Target |
Literature-reported |
||||
| Drug Potency against Target | Gentamicin | Drug Info | IC50 = 140000 nM | [2] | |
| Adenosine triphosphate | Drug Info | IC50 = 17300 nM | [1] | ||
| NSC-119911 | Drug Info | IC50 = 2730 nM | [1] | ||
| NSC-119913 | Drug Info | IC50 = 5580 nM | [1] | ||
| References | |||||
| REF 1 | In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. | ||||
| REF 2 | Gentamicin inhibits HSP70-assisted protein folding by interfering with substrate recognition. FEBS Lett. 2010 Feb 19;584(4):645-51. | ||||
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