Target Validation Information
TTD ID	T10937
Target Name	Mdm2 messenger RNA (MDM2 mRNA)
Type of Target	Literature-reported
Drug Potency against Target	NSC-66811	Drug Info	Ki = 120 nM	[2]
	NU-8231	Drug Info	IC50 = 5300 nM	[3]
	NUTLIN-3	Drug Info	IC50 = 90 nM	[4]
	PLSQETFSDLWKLLPEN-NH2	Drug Info	Ki = 6670 nM	[1]
References
REF 1	Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction. J Med Chem. 2006 Jun 15;49(12):3432-5.
REF 2	Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening str... J Med Chem. 2006 Jun 29;49(13):3759-62.
REF 3	Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold. J Med Chem. 2006 Oct 19;49(21):6209-21.
REF 4	Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature. 2007 Dec 13;450(7172):1001-9.

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