Target Validation Information | |||||
---|---|---|---|---|---|
TTD ID | T10513 | ||||
Target Name | Integrin beta-2 (ITGB2) | ||||
Type of Target |
Clinical trial |
||||
Drug Potency against Target | A-286982 | Drug Info | IC50 = 44 nM | [1] | |
BMS-587101 | Drug Info | IC50 = 20 nM | [2] | ||
References | |||||
REF 1 | Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism o... J Med Chem. 2001 Apr 12;44(8):1202-10. | ||||
REF 2 | Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thioph... J Med Chem. 2006 Nov 30;49(24):6946-9. | ||||
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