Target Validation Information
TTD ID	T06671
Target Name	Interleukin-18 (IL18)
Type of Target	Clinical trial
Drug Potency against Target	Iboctadekin + rituximab	Drug Info	Ki = 300000 nM	[2]
Action against Disease Model	IL-18BP	Drug Info	Levels of IL-18 were found to correlate with ser uM ferritin values and disease severity in adult-onset Still's disease (ASD). Western blot analysis revealed that ser uM samplesfrom patients with active ASD contained an 18-kd polypeptide of IL-18, corresponding in size to the mature form. Accordingly, the samples were able to induce IFNgamma secretion from KG-1 cells, whichwas largely abolished by neutralizing anti-IL-18 antibody.	[1]
References
REF 1	Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease. Arthritis Rheum. 2001 Mar;44(3):550-60.
REF 2	Recent developments of structure based beta-secretase inhibitors for Alzheimer's disease. Curr Top Med Chem. 2005;5(16):1609-22.

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