Target Validation Information
TTD ID	T04902
Target Name	Calpain-2 (CAPN2)
Type of Target	Clinical trial
Drug Potency against Target		Drug Info	IC50 = 70 nM	[4]
	(1-Benzyl-2-oxo-ethyl)-carbamic acid benzyl ester	Drug Info	Ki = 3000 nM	[6]
	3-(1H-Pyrrol-3-yl)-propionamide	Drug Info	IC50 = 1400 nM
	Aloxistatin	Drug Info	IC50 = 1774.2 nM	[5]
	AW-00430	Drug Info	IC50 = 12237.9 nM	[5]
	BITHIONOL	Drug Info	IC50 = 4751.15 nM	[5]
	DIHYDROXANTHOHUMOL	Drug Info	IC50 = 5000.36 nM	[5]
	GNF-PF-4453	Drug Info	IC50 = 3921.06 nM	[5]
	MDL-28170	Drug Info	Ki = 10 nM	[1]
	N-(1-Benzyl-2-oxo-ethyl)-benzamide	Drug Info	Ki = 4000 nM	[6]
	SJA-6017	Drug Info	IC50 = 7.5 nM	[3]
	SJA-6017	Drug Info	IC50 = 86 nM	[2]
References
REF 1	Synthesis of a small library of diketopiperazines as potential inhibitors of calpain. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3034-8.
REF 2	Exploration of orally available calpain inhibitors 2: peptidyl hemiacetal derivatives. J Med Chem. 2006 Jun 29;49(13):3926-32.
REF 3	Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors. Bioorg Med Chem. 2008 Jul 15;16(14):6911-23.
REF 4	Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):502-7.
REF 5	In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
REF 6	Alpha-diketone and alpha-keto ester derivatives of N-protected amino acids and peptides as novel inhibitors of cysteine and serine proteinases. J Med Chem. 1990 Jan;33(1):11-3.

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