Target Validation Information
TTD ID	T04507
Target Name	Presynaptic density protein 95 (DLG4)
Type of Target	Clinical trial
Drug Potency against Target	FETAV	Drug Info	Ki = 2300 nM	[1]
	KSG-LDTKNYKQTSV	Drug Info	Ki = 2100 nM	[1]
	KSG-YEKLSSIESDV	Drug Info	Ki = 7000 nM	[1]
	N-(3,4-Dichlorophenyl)propyl-ETAV	Drug Info	Ki = 1100 nM	[1]
	N-(3,4-Difluorophenyl)propyl-ETAV	Drug Info	Ki = 1000 nM	[1]
	N-(Naphthalene-2-yl)ethyl-ETAV	Drug Info	Ki = 950 nM	[1]
	N-Benzyl-ETAV	Drug Info	Ki = 5200 nM	[1]
	N-Butyl-ETAV	Drug Info	Ki = 4000 nM	[1]
	N-Cyclohexylethyl-ETAV	Drug Info	Ki = 450 nM	[1]
	N-Cyclohexylmethyl-ETAV	Drug Info	Ki = 1300 nM	[1]
	N-Ethyl-ETAV	Drug Info	Ki = 9600 nM	[1]
	N-Methyl-ETAV	Drug Info	Ki = 8900 nM	[1]
	N-Phenylethyl-ETAV	Drug Info	Ki = 1600 nM	[1]
	N-Phenylpropyl-ETAV	Drug Info	Ki = 3100 nM	[1]
	N-Propyl-ETAV	Drug Info	Ki = 4200 nM	[1]
	YGRKKRRQRRR-KLSSIESDV	Drug Info	Ki = 14000 nM	[1]
References
REF 1	Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9.

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