Target Validation Information
TTD ID	T02677
Target Name	Apoptosis inhibitor survivin (BIRC5)
Type of Target	Clinical trial
Drug Potency against Target	Terameprocol	Drug Info	IC50 = 200 nM	[2]
Action against Disease Model	Terameprocol	Drug Info	Potent anticancer activity in t uMour cell lines and animal models; good safety and efficacy profile in patients with head and neck or squamous cell carcinoma (intrat uMoral administration) and in patients with cervical dysplasia (intravaginal administration).	[1]
References
REF 1	Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66.
REF 2	Centrosome amplification induced by survivin suppression enhances both chromosome instability and radiosensitivity in glioma cells. Br J Cancer. 2008 Jan 29;98(2):345-55.

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