| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T02546 | ||||
| Target Name | Voltage-gated sodium channel alpha Nav1.4 (SCN4A) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | 3-(4-Phenoxy-phenyl)-1H-pyrazole | Drug Info | Ki = 240 nM | [1] | |
| 3-[4-(4-Fluoro-phenoxy)-phenyl]-1H-pyrazole | Drug Info | Ki = 200 nM | [1] | ||
| V-102862 | Drug Info | Ki = 180 nM | [1] | ||
| References | |||||
| REF 1 | 3-(4-phenoxyphenyl)pyrazoles: a novel class of sodium channel blockers. J Med Chem. 2004 Mar 11;47(6):1547-52. | ||||
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