Target Regulator(s) Information (Transcription Factor)
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T73475 | Target Info | |||
| Target Name | Matrix metalloproteinase-7 (MMP-7) | ||||
| Synonyms | Uterine metalloproteinase; Pump-1 protease; PUMP1; Matrin; Matrilysin; MPSL1 | ||||
| Target Type | Successful Target | ||||
| Gene Name | MMP7 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| The Transcription Factors (TFs) Regulating This Target | Top | ||||
|---|---|---|---|---|---|
| TF Name | Transcription factor 7-like 2 (TCF7L2) | ||||
| Classification | Superclass | beta-Scaffold Factors with Minor Groove Contacts | |||
| Class | HMG | ||||
| Regulation Mechanism | TCF binding sites are identified in the human MMP-7 promoter. | [1] | |||
| Evidence Score (E-score) | 2 | + | |||
| 1 | Chromatin Immunoprecipitation Assay | [2] | |||
| 2 | Electrophoretic Mobility Shift Assay, Reporter Assay | [1] | |||
| UniProt ID | |||||
| Sequence |
MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS
DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS LSPTARTLHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSP AHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDIS PYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPP HHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLY MKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSAR DNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPC RRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKP DPLAHLSMMPPPPALLLAEATHKASALCPNGALDLPPAALQPAAPSSSIAQPSTSSLHSH SSLAGTQPQPLSLVTKSLE |
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| The Genes (Co-regulated by This TF) Grouped Based on Their Biochemical Classes | |||||
| Peptidases | [+] 1 Peptidases Co-regulated By This TF | + | |||
| 1 | Matrix metalloproteinase-7 (MMP-7) | Successful Target | Target Info | [1] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am J Pathol. 1999 Oct;155(4):1033-8. | ||||
| REF 2 | Metoprolol represses PGC1alpha-mediated carnitine palmitoyltransferase-1B expression in the diabetic heart. Eur J Pharmacol. 2009 Apr 1;607(1-3):156-66. | ||||
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