Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99909 | Target Info | |||
| Target Name | Mortalin (HSPA9) | ||||
| Synonyms | mt-HSP70; Stress-70 protein, mitochondrial; Peptide-binding protein 74; PBP74; MOT; Heat shock 70 kDa protein 9; HSPA9B; GRP75; GRP-75; 75 kDa glucose-regulated protein | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | HSPA9 | ||||
| Biochemical Class | Heat shock protein | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Cell cycle related proteins | [+] 1 Cell cycle related proteins | + | |||
| Interacting Target Name | Multiple tumor suppressor 1 (CDKN2A) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Tumour suppressor gene p16; P16-INK4a; p16INK4A; P16-INK4; P16 gene; MTS-1; Cyclin-dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; CDK4I | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Reconstituted Complex | [2] | |||
| Kinases | [+] 1 Kinases | + | |||
| Interacting Target Name | Serine/threonine-protein kinase B-raf (BRAF) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | V-Raf murine sarcoma viral oncogene homolog B1; Serine/threonine-protein kinase B-raf; RAFB1; Proto-oncogene B-Raf; P94; BRAF1; BRAF(V599E); BRAF serine/threonine kinase; B-raf protein; B-Raf | ||||
| Evidence Score (E-score) | 1 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [3] | |||
| Pore-forming toxins | [+] 1 Pore-forming toxins | + | |||
| Interacting Target Name | Cellular tumor antigen p53 (TP53) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [4] | |||
| 2 | Affinity Capture-Western | [5] | |||
| 3 | Yeast two hybrid | [6] | |||
| Other proteins | [+] 1 Other proteins | + | |||
| Interacting Protein Name | DNL-type zinc finger protein (DNLZ) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | C9orf151; HEP; HEP1; TIMM15; ZIM17; bA413M3.2 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [7] | |||
| 2 | Reconstituted Complex | [8] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | ARF induces autophagy by virtue of interaction with Bcl-xl. J Biol Chem. 2009 Jan 30;284(5):2803-10. | ||||
| REF 2 | Proteomic analysis of p16ink4a-binding proteins. Proteomics. 2007 Nov;7(22):4102-11. | ||||
| REF 3 | A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes. Proteomics. 2007 Dec;7(23):4228-34. | ||||
| REF 4 | Autophagic degradation of the inhibitory p53 isoform 133p53 as a regulatory mechanism for p53-mediated senescence. Nat Commun. 2014 Aug 21;5:4706. | ||||
| REF 5 | Identification of differential proteins in nasopharyngeal carcinoma cells with p53 silence by proteome analysis. FEBS Lett. 2007 Jan 9;581(1):131-9. | ||||
| REF 6 | Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein. Exp Cell Res. 2002 Apr 1;274(2):246-53. | ||||
| REF 7 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
| REF 8 | The DNLZ/HEP zinc-binding subdomain is critical for regulation of the mitochondrial chaperone HSPA9. Protein Sci. 2012 Feb;21(2):258-67. | ||||
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