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| Target General Information |
Top |
| Target ID |
T97537 |
Target Info
|
| Target Name |
Leucyl-cysteinyl aminopeptidase (LNPEP) |
| Synonyms |
Placental leucine aminopeptidase; P-LAP; Oxytocinase; OTase; Leucyl-cystinyl aminopeptidase; Insulin-responsive aminopeptidase; Insulin-regulated membrane aminopeptidase; IRAP; Cystinyl aminopeptidase |
| Target Type |
Patented-recorded Target |
| Gene Name |
LNPEP |
| Biochemical Class |
Peptidase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Glycosyltransferases |
[+] 1 Glycosyltransferases |
+ |
| Interacting Target Name |
Tankyrase-2 (TNKS-2) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
TRF1-interacting ankyrin-related ADP-ribose polymerase 2; TNKL; Tankyrase-related protein; Tankyrase-like protein; Tankyrase II; TANK2; Protein poly-ADP-ribosyltransferase tankyrase-2; Poly [ADP-ribose] polymerase tankyrase-2; Poly [ADP-ribose] polymerase 5B; PARP5B; ARTD6; ADP-ribosyltransferase diphtheria toxin-like 6 |
| Evidence Score (E-score) |
5 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Reconstituted Complex |
[2] |
| 3 |
Reconstituted Complex |
[1] |
| 4 |
Reconstituted Complex |
[3] |
| 5 |
Yeast two hybrid |
[3] |
| References |
Top |
| REF 1 |
Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase). Biochem J. 2002 Feb 1;361(Pt 3):451-9.
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| REF 2 |
Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a nov... J Biol Chem. 2002 Aug 30;277(35):31887-92.
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| REF 3 |
Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles. J Biol Chem. 2000 Dec 8;275(49):38437-44.
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