Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T96669 Target Info
Target Name Clusterin (CLU)
Synonyms Testosteronerepressed prostate message 2; Testosterone-repressed prostate message 2; TRPM-2; NA1/NA2; Ku70binding protein 1; Ku70-binding protein 1; KUB1; Complementassociated protein SP40,40; Complement-associated protein SP-40,40; Complement cytolysis inhibitor; Clusterin alpha chain; CLI; Apolipoprotein J; ApoJ; Apo-J; Agingassociated gene 4 protein; Aging-associated gene 4 protein; AAG4
Target Type Literature-reported Target
Gene Name CLU
UniProt ID
CLUS_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Protein Name X-ray repair cross-complementing protein 6 (XRCC6) Interacting Protein Interacting Protein Info
UniProt ID
XRCC6_HUMAN 
Synonyms CTC75; CTCBF; G22P1; KU70; ML8; TLAA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Yeast two hybrid [2]
Interacting Target Name Endoplasmic reticulum chaperone BiP (HSPA5) Clinical trial Target Interacting Protein Info
UniProt ID
BIP_HUMAN 
Synonyms Immunoglobulin heavy chain-binding protein; Immunoglobulin heavy chainbinding protein; HSP70 family protein 5; Heat shock protein family A member 5; Heat shock protein 70 family protein 5; Heat shock 70 kDa protein 5; GRP-78; GRP78; Endoplasmic reticulum lumenal Ca(2+)binding protein grp78; BiP; Binding-immunoglobulin protein; 78 kDa glucose-regulated protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Amyloid beta A4 protein (APP) Successful Target Interacting Protein Info
UniProt ID
A4_HUMAN 
Synonyms Vascular beta-amyloid; Protease nexin-II; PreA4; PN-II; CVAP; Cerebral vascular amyloidpeptide; Cerebral vascular amyloid peptide; Beta-amyloid peptide; APPI; Amyloid-beta precursor protein; Amyloid-beta A4 protein; Amyloid precursor protein; Amyloid beta precursor protein; Alzheimer's disease amyloid protein; Alzheimer disease amyloid protein; AD1; ABPP; A4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Fluorescence Resonance Energy Transfer [5]
3 Reconstituted Complex [6]
Other proteins [+] 1 Other proteins +
Interacting Protein Name COMM domain-containing protein 1 (COMMD1) Interacting Protein Interacting Protein Info
UniProt ID
COMD1_HUMAN 
Synonyms C2orf5; MURR1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Yeast two hybrid [7]
References  Top
REF 1 Isolation of Ku70-binding proteins (KUBs). Nucleic Acids Res. 1999 May 15;27(10):2165-74.
REF 2 Synthesis and functional analyses of nuclear clusterin, a cell death protein. J Biol Chem. 2003 Mar 28;278(13):11590-600.
REF 3 GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer. Oncogene. 2013 Apr 11;32(15):1933-42.
REF 4 Clusterin protects hepatocellular carcinoma cells from endoplasmic reticulum stress induced apoptosis through GRP78. PLoS One. 2013;8(2):e55981.
REF 5 Direct Interaction of Selenoprotein R with Clusterin and Its Possible Role in Alzheimer's Disease. PLoS One. 2013 Jun 21;8(6):e66384.
REF 6 Clusterin Binds to A1-42 Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation. J Biol Chem. 2016 Mar 25;291(13):6958-66.
REF 7 Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells. Mol Cancer Res. 2010 Jan;8(1):119-30.

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