Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T96396 | Target Info | |||
| Target Name | Prohibitin (PHB) | ||||
| Synonyms | PHB1; HEL-S-54e; HEL-215 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | PHB | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Carbon-nitrogen hydrolases | [+] 2 Carbon-nitrogen hydrolases | + | |||
| Interacting Target Name | Histone deacetylase 1 (HDAC1) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | RPD3L1; HD1 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Reconstituted Complex | [2] | |||
| Interacting Target Name | Histone deacetylase 5 (HDAC5) | Patented-recorded Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | KIAA0600; HD5; Antigen NY-CO-9 | ||||
| Evidence Score (E-score) | 1 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [3] | |||
| Kinases | [+] 1 Kinases | + | |||
| Interacting Target Name | Proto-oncogene c-RAF (c-RAF) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Raf-1; RAF proto-oncogene serine/threonine-protein kinase; RAF; cRaf | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [4] | |||
| 2 | Affinity Capture-Western | [5] | |||
| 3 | Reconstituted Complex | [4] | |||
| Transcription regulators | [+] 1 Transcription regulators | + | |||
| Interacting Target Name | E2F transcription factor 1 (E2F1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Transcription factor E2F1; Retinoblastoma-binding protein 3; Retinoblastoma-associated protein 1; RBBP-3; RBBP3; RBAP-1; pRB-binding protein E2F-1; PBR3; E2F-1 | ||||
| Evidence Score (E-score) | 6 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [2] | |||
| 2 | Affinity Capture-Western | [6] | |||
| 3 | Affinity Capture-Western | [7] | |||
| 4 | Co-localization | [8] | |||
| 5 | Reconstituted Complex | [2] | |||
| 6 | Reconstituted Complex | [4] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A repressive role for prohibitin in estrogen signaling. Mol Endocrinol. 2008 Feb;22(2):344-60. | ||||
| REF 2 | A putative coiled-coil domain of prohibitin is sufficient to repress E2F1-mediated transcription and induce apoptosis. Biochem Biophys Res Commun. 2003 Dec 12;312(2):459-66. | ||||
| REF 3 | Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. Mol Cell Proteomics. 2011 Feb;10(2):M110.004317. | ||||
| REF 4 | Rb and prohibitin target distinct regions of E2F1 for repression and respond to different upstream signals. Mol Cell Biol. 1999 Nov;19(11):7447-60. | ||||
| REF 5 | Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration. Nat Cell Biol. 2005 Aug;7(8):837-43. | ||||
| REF 6 | Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth. EMBO J. 2002 Jun 17;21(12):3019-28. | ||||
| REF 7 | BRG1/BRM and prohibitin are required for growth suppression by estrogen antagonists. EMBO J. 2004 Jun 2;23(11):2293-303. | ||||
| REF 8 | Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling. J Biol Chem. 2003 Nov 28;278(48):47853-61. | ||||
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