Target Interacting Protein Information
Target General Information | Top | ||||
---|---|---|---|---|---|
Target ID | T95183 | Target Info | |||
Target Name | Ubiquitin carboxyl-terminal hydrolase 2 (USP2) | ||||
Synonyms | Ubiquitin-specific-processing protease 2; Ubiquitin thioesterase 2; UBP41; Deubiquitinating enzyme 2; 41 kDa ubiquitin-specific protease | ||||
Target Type | Preclinical Target | ||||
Gene Name | USP2 | ||||
Biochemical Class | Peptidase | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
---|---|---|---|---|---|
Acyltransferases | [+] 3 Acyltransferases | + | |||
Interacting Target Name | Fatty acid synthase (FASN) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Yeast fatty acid synthase; Fatty-acyl-CoA synthase; Fatty acyl-CoA synthetase enzyme; FAS | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [2] | |||
3 | Affinity Capture-Western | [1] | |||
4 | Biochemical Activity | [1] | |||
Interacting Target Name | TNF receptor-associated factor 6 (TRAF6) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [3] | |||
2 | Biochemical Activity | [4] | |||
3 | Biochemical Activity | [3] | |||
4 | Yeast two hybrid | [5] | |||
Interacting Protein Name | TNF receptor-associated factor 2 (TRAF2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | MGC:45012; TRAP; TRAP3 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [6] | |||
2 | Affinity Capture-Western | [7] | |||
3 | Biochemical Activity | [7] | |||
Kinases | [+] 1 Kinases | + | |||
Interacting Target Name | Receptor-interacting protein 1 (RIPK1) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RIP-1; RIP1; RIP; Receptor-interacting serine/threonine-protein kinase 1; Cell death protein RIP | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [6] | |||
2 | Affinity Capture-Western | [7] | |||
3 | Biochemical Activity | [7] | |||
Peptidases | [+] 1 Peptidases | + | |||
Interacting Protein Name | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | IMD12; MLT; MLT1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [3] | |||
2 | Biochemical Activity | [8] | |||
Ubiquitin related proteins | [+] 1 Ubiquitin related proteins | + | |||
Interacting Target Name | Polyubiquitin-C (UBC) | Patented-recorded Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | HMG20; ubiquitin C | ||||
Evidence Score (E-score) | 18 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [9] | |||
2 | Biochemical Activity | [4] | |||
3 | Biochemical Activity | [10] | |||
4 | Biochemical Activity | [11] | |||
5 | Biochemical Activity | [12] | |||
6 | Biochemical Activity | [13] | |||
7 | Biochemical Activity | [14] | |||
8 | Biochemical Activity | [15] | |||
9 | Biochemical Activity | [16] | |||
10 | Biochemical Activity | [17] | |||
11 | Biochemical Activity | [18] | |||
12 | Biochemical Activity | [19] | |||
13 | Biochemical Activity | [20] | |||
14 | Co-crystal Structure | [21] | |||
15 | Co-crystal Structure | [22] | |||
16 | Protein-peptide | [22] | |||
17 | Reconstituted Complex | [15] | |||
18 | Reconstituted Complex | [23] |
References | Top | ||||
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REF 1 | The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer. Cancer Cell. 2004 Mar;5(3):253-61. | ||||
REF 2 | The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer. Cell Cycle. 2012 Mar 15;11(6):1123-30. | ||||
REF 3 | USP2a positively regulates TCR-induced NF-B activation by bridging MALT1-TRAF6. Protein Cell. 2013 Jan;4(1):62-70. | ||||
REF 4 | Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Nat Struct Mol Biol. 2010 Aug;17(8):939-47. | ||||
REF 5 | A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226. | ||||
REF 6 | De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1. Biochim Biophys Acta. 2012 Aug;1823(8):1353-65. | ||||
REF 7 | De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF. Cell Death Differ. 2012 May;19(5):891-9. | ||||
REF 8 | Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation. PLoS One. 2017 Jan 4;12(1):e0169026. | ||||
REF 9 | Large-scale analysis of the human ubiquitin-related proteome. Proteomics. 2005 Nov;5(16):4145-51. | ||||
REF 10 | Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. EMBO J. 2015 Feb 3;34(3):307-25. | ||||
REF 11 | Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep. 2009 May;10(5):466-73. | ||||
REF 12 | The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability. Hum Mol Genet. 2011 Jan 1;20(1):141-54. | ||||
REF 13 | Internally tagged ubiquitin: a tool to identify linear polyubiquitin-modified proteins by mass spectrometry. Nat Methods. 2017 May;14(5):504-512. | ||||
REF 14 | Divergence in Ubiquitin Interaction and Catalysis among the Ubiquitin-Specific Protease Family Deubiquitinating Enzymes. Biochemistry. 2016 Aug 23;55(33):4708-19. | ||||
REF 15 | Transient kinetic analysis of USP2-catalyzed deubiquitination reveals a conformational rearrangement in the K48-linked diubiquitin substrate. Biochemistry. 2012 Dec 18;51(50):10075-86. | ||||
REF 16 | Wss1 is a SUMO-dependent isopeptidase that interacts genetically with the Slx5-Slx8 SUMO-targeted ubiquitin ligase. Mol Cell Biol. 2010 Aug;30(15):3737-48. | ||||
REF 17 | Evolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family. PLoS One. 2015 Nov 20;10(11):e0143227. | ||||
REF 18 | Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins. Structure. 2016 Mar 1;24(3):423-36. | ||||
REF 19 | The molecular determinants for distinguishing between ubiquitin and NEDD8 by USP2. Sci Rep. 2017 May 23;7(1):2304. | ||||
REF 20 | Method for the Purification of Endogenous Unanchored Polyubiquitin Chains. Methods Mol Biol. 2016;1449:203-13. | ||||
REF 21 | Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. Structure. 2006 Aug;14(8):1293-302. | ||||
REF 22 | A strategy for modulation of enzymes in the ubiquitin system. Science. 2013 Feb 1;339(6119):590-5. | ||||
REF 23 | Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8705-10. |
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