Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T93923 Target Info
Target Name Co-stimulatory molecule 4-1BB (CD137)
Synonyms Tumor necrosis factor receptor superfamily member 9; T-cell antigen ILA; T-cell antigen 4-1BB homolog; ILA; CDw137; 4-1BB ligand receptor
Target Type Clinical trial Target
Gene Name TNFRSF9
Biochemical Class Cytokine receptor
UniProt ID
TNR9_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name TNF receptor-associated factor 2 (TRAF2) Interacting Protein Interacting Protein Info
UniProt ID
TRAF2_HUMAN 
Synonyms MGC:45012; TRAP; TRAP3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [2]
4 Yeast two hybrid [3]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name TNF receptor-associated factor 1 (TRAF1) Interacting Protein Interacting Protein Info
UniProt ID
TRAF1_HUMAN 
Synonyms EBI6; MGC:10353
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Reconstituted Complex [4]
3 Reconstituted Complex [2]
References  Top
REF 1 T cell costimulation with anti-CD137 monoclonal antibodies is mediated by K63-polyubiquitin-dependent signals from endosomes. J Immunol. 2013 Jun 15;190(12):6694-706.
REF 2 CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand. J Exp Med. 1998 Jun 1;187(11):1849-62.
REF 3 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. Mol Cell Biol. 1998 Jan;18(1):558-65.
REF 4 Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B. Biochem Biophys Res Commun. 1998 Jan 26;242(3):613-20.

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