Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T92803 Target Info
Target Name Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A)
Synonyms hMNB; Protein kinase minibrain homolog; MNBH; MNB; HP86; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; DYRK
Target Type Patented-recorded Target
Gene Name DYRK1A
Biochemical Class Kinase
UniProt ID
DYR1A_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name Dynamin-1 (DNM1) Interacting Protein Interacting Protein Info
UniProt ID
DYN1_HUMAN 
Synonyms DNM
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Reconstituted Complex [2]
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name DDB1- and CUL4-associated factor 7 (DCAF7) Interacting Protein Interacting Protein Info
UniProt ID
DCAF7_HUMAN 
Synonyms AN11; HAN11; SWAN.1; WDR68
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [5]
5 Affinity Capture-Western [6]
6 Co-localization [7]
7 Co-localization [3]
8 Reconstituted Complex [6]
References  Top
REF 1 Dyrk1A binds to multiple endocytic proteins required for formation of clathrin-coated vesicles. Biochemistry. 2009 Oct 6;48(39):9297-305.
REF 2 Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate. J Biol Chem. 2002 May 17;277(20):17597-604.
REF 3 DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation. Biochim Biophys Acta. 2011 Oct;1813(10):1728-39.
REF 4 The protein interaction landscape of the human CMGC kinase group. Cell Rep. 2013 Apr 25;3(4):1306-20.
REF 5 The molecular chaperone TRiC/CCT binds to the Trp-Asp 40 (WD40) repeat protein WDR68 and promotes its folding, protein kinase DYRK1A binding, and nuclear accumulation. J Biol Chem. 2014 Nov 28;289(48):33320-32.
REF 6 The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2. Sci Rep. 2016 Jun 16;6:28241.
REF 7 The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions. EMBO J. 2010 Nov 17;29(22):3750-61.

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