Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T92076 Target Info
Target Name Extracellular calcium-sensing receptor (CASR)
Synonyms hCasR; Parathyroid cell calciumreceptor; Parathyroid cell calcium-sensing receptor 1; Parathyroid calcium receptor; Parathyroid Cell calcium-sensing receptor; PCaR1; GPRC2A; CaSR
Target Type Successful Target
Gene Name CASR
Biochemical Class GPCR glutamate
UniProt ID
CASR_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Target Name Filamin A (FLNA) Clinical trial Target Interacting Protein Info
UniProt ID
FLNA_HUMAN 
Synonyms Non-muscle filamin; Nonmuscle filamin; FLN-A; FLN1; FLN; Filamin-A; Filamin-1; Filamin 1; Endothelial actin-binding protein; Endothelial actin cytoskeleton; Alpha-filamin; Actin-binding protein 280; ABP-280
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Yeast two hybrid [2]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Reconstituted Complex [4]
References  Top
REF 1 Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein. J Biol Chem. 2001 Sep 14;276(37):34871-9.
REF 2 Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinase. J Biol Chem. 2001 Sep 14;276(37):34880-7.
REF 3 Inhibitor of nuclear factor-kappaB alpha derepresses hypoxia-inducible factor-1 during moderate hypoxia by sequestering factor inhibiting hypoxia-inducible factor from hypoxia-inducible factor 1alpha. FEBS J. 2009 Jul;276(13):3470-80.
REF 4 von Hippel-Lindau protein adjusts oxygen sensing of the FIH asparaginyl hydroxylase. Int J Biochem Cell Biol. 2011 May;43(5):795-804.

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