Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T90113 Target Info
Target Name Ubiquitin-protein ligase E2 (UBE2E2)
Synonyms Ubiquitin-conjugating enzyme E2 E2; Ubiquitin carrier protein E2; UbcH8; E2 ubiquitin-conjugating enzyme E2
Target Type Literature-reported Target
Gene Name UBE2E2
Biochemical Class Ubiquitin-conjugating enzyme
UniProt ID
UB2E2_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 6 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase RNF14 (RNF14) Interacting Protein Interacting Protein Info
UniProt ID
RNF14_HUMAN 
Synonyms ARA54; HFB30; TRIAD2
Evidence Score (E-score) 3 Experimental Evidences +
1 Yeast two hybrid [1]
2 Yeast two hybrid [2]
3 Yeast two hybrid [3]
Interacting Protein Name E3 ubiquitin-protein ligase RNF8 (RNF8) Interacting Protein Interacting Protein Info
UniProt ID
RNF8_HUMAN 
Synonyms hRNF8
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [5]
3 Yeast two hybrid [1]
Interacting Protein Name E3 ubiquitin-protein ligase RLIM (RLIM) Interacting Protein Interacting Protein Info
UniProt ID
RNF12_HUMAN 
Synonyms NY.REN.43; RNF12
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Yeast two hybrid [2]
Interacting Protein Name E3 ubiquitin-protein ligase RNF25 (RNF25) Interacting Protein Interacting Protein Info
UniProt ID
RNF25_HUMAN 
Synonyms AO7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Yeast two hybrid [2]
Interacting Protein Name E3 ubiquitin-protein ligase Midline-1 (MID1) Interacting Protein Interacting Protein Info
UniProt ID
TRI18_HUMAN 
Synonyms BBBG1; FXY; GBBB1; MIDIN; OGS1; OS; OSX; RNF59; TRIM18; XPRF; ZNFXY
Evidence Score (E-score) 2 Experimental Evidences +
1 Yeast two hybrid [8]
2 Yeast two hybrid [2]
Interacting Protein Name Probable E3 ubiquitin-protein ligase MID2 (MID2) Interacting Protein Interacting Protein Info
UniProt ID
TRIM1_HUMAN 
Synonyms FXY2; MRX101; RNF60; TRIM1
Evidence Score (E-score) 2 Experimental Evidences +
1 Yeast two hybrid [8]
2 Yeast two hybrid [9]
References  Top
REF 1 N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. Eur J Biochem. 2001 May;268(9):2725-32.
REF 2 Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. Genome Res. 2009 Oct;19(10):1905-11.
REF 3 Mulan E3 ubiquitin ligase interacts with multiple E2 conjugating enzymes and participates in mitophagy by recruiting GABARAP. Cell Signal. 2014 Dec;26(12):2921-9.
REF 4 HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes. Nat Cell Biol. 2010 Jan;12(1):80-6; sup pp 1-12.
REF 5 Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation. Nucleic Acids Res. 2012 Jan;40(1):196-205.
REF 6 Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha. FASEB J. 2008 May;22(5):1369-79.
REF 7 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 8 Functional interactions between ubiquitin E2 enzymes and TRIM proteins. Biochem J. 2011 Mar 1;434(2):309-19.
REF 9 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.