Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T89055 | Target Info | |||
| Target Name | ERK activator kinase 2 (MEK2) | ||||
| Synonyms | PRKMK2; MKK2; MEK 2; MAPKK 2; MAPK/ERK kinase 2; MAP kinase kinase 2; Dual specificity mitogenactivated protein kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 2 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | MAP2K2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Kinases | [+] 5 Kinases | + | |||
| Interacting Target Name | Extracellular signal-regulated kinase 2 (ERK2) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | PRKM2; PRKM1; P42-MAPK; P42 Mitogen-activated protein kinase; Mitogen-activated protein kinase 2; Mitogen-activated protein kinase 1; MAPK 2; MAPK 1; MAP kinase isoform p42; MAP kinase 2; MAP kinase 1; ERT1; ERK-2 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Biochemical Activity | [1] | |||
| 2 | Reconstituted Complex | [1] | |||
| 3 | Yeast two hybrid | [2] | |||
| Interacting Target Name | Extracellular signal-regulated kinase 1 (ERK1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | PRKM3; P44-MAPK; P44-ERK1; P44 Mitogen-activated protein kinase; Mitogen-activated protein kinase 3; Microtubule-associated protein-2 kinase; Microtubule-associated protein 2 kinase; MAPK 3; MAP kinase isoform p44; MAP kinase 3; Insulin-stimulated MAP2 kinase; ERT2; ERK-1 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Biochemical Activity | [3] | |||
| 2 | Reconstituted Complex | [4] | |||
| 3 | Yeast two hybrid | [5] | |||
| Interacting Protein Name | Proto-oncogene A-Raf (ARAF ) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Serine/threonine-protein kinase A-Raf; Proto-oncogene Pks; Proto-oncogene A-Raf-1; Proto-oncogene A-Raf; PKS2; PKS; ARAF1 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [6] | |||
| 2 | Reconstituted Complex | [7] | |||
| 3 | Yeast two hybrid | [8] | |||
| Interacting Target Name | Proto-oncogene c-RAF (c-RAF) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Raf-1; RAF proto-oncogene serine/threonine-protein kinase; RAF; cRaf | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [9] | |||
| 2 | Yeast two hybrid | [8] | |||
| Interacting Target Name | Serine/threonine-protein kinase B-raf (BRAF) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | V-Raf murine sarcoma viral oncogene homolog B1; Serine/threonine-protein kinase B-raf; RAFB1; Proto-oncogene B-Raf; P94; BRAF1; BRAF(V599E); BRAF serine/threonine kinase; B-raf protein; B-Raf | ||||
| Evidence Score (E-score) | 1 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [10] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates. J Biol Chem. 2003 Aug 29;278(35):32662-72. | ||||
| REF 2 | Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1. J Biol Chem. 2002 Apr 26;277(17):14844-52. | ||||
| REF 3 | Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2. J Biol Chem. 1996 Feb 23;271(8):4230-5. | ||||
| REF 4 | Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases. J Biol Chem. 1993 Nov 15;268(32):23933-9. | ||||
| REF 5 | Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells. J Biol Chem. 1997 Jan 31;272(5):2620-8. | ||||
| REF 6 | Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Sci Signal. 2015 Apr 7;8(371):rs3. | ||||
| REF 7 | Identification of interaction between MEK2 and A-Raf-1. Biochim Biophys Acta. 2002 Feb 13;1589(1):71-6. | ||||
| REF 8 | Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536. | ||||
| REF 9 | JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. Genes Dev. 1998 Nov 1;12(21):3369-81. | ||||
| REF 10 | A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes. Proteomics. 2007 Dec;7(23):4228-34. | ||||
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