Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T87686 Target Info
Target Name Histone-lysine N-methyltransferase (HLNM)
Synonyms Lysine N-methyltransferase 4; KMT4; KIAA1814; Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone H3-K79 methyltransferase; H3-K79-HMTase; DOT1-like protein
Target Type Clinical trial Target
Gene Name DOT1L
Biochemical Class Methyltransferase
UniProt ID
DOT1L_HUMAN 
Target Interacting Proteins  Top
Histones [+] 1 Histones +
Interacting Protein Name Histone H3.2 (H32) Interacting Protein Interacting Protein Info
UniProt ID
H32_HUMAN 
Synonyms H3; H3.2; H3/M; H3F2; H3FM; H3FN
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
Transcription regulators [+] 2 Transcription regulators +
Interacting Protein Name Protein AF-17 (MLLT6) Interacting Protein Interacting Protein Info
UniProt ID
AF17_HUMAN 
Synonyms AF17
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Co-fractionation [4]
3 Yeast two hybrid [5]
Interacting Protein Name Protein AF-10 (MLLT10) Interacting Protein Interacting Protein Info
UniProt ID
AF10_HUMAN 
Synonyms AF10
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-MS [3]
Other proteins [+] 2 Other proteins +
Interacting Protein Name YEATS domain-containing protein 3 (MLLT3) Interacting Protein Interacting Protein Info
UniProt ID
AF9_HUMAN 
Synonyms AF9; YEATS3
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [7]
4 Affinity Capture-Western [8]
5 Yeast two hybrid [7]
Interacting Protein Name YEATS domain-containing protein 1 (MLLT1) Interacting Protein Interacting Protein Info
UniProt ID
ENL_HUMAN 
Synonyms ENL; LTG19; YEATS1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [9]
4 Affinity Capture-Western [8]
References  Top
REF 1 Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases. EMBO J. 2012 May 2;31(9):2169-81.
REF 2 The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. Mol Cell. 2011 Jul 8;43(1):132-44.
REF 3 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 4 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 5 AF17 competes with AF9 for binding to Dot1a to up-regulate transcription of epithelial Na+ channel alpha. J Biol Chem. 2009 Dec 18;284(51):35659-69.
REF 6 Characterization of the DOT1L network: implications of diverse roles for DOT1L. Protein J. 2010 Apr;29(3):213-23.
REF 7 Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner. J Biol Chem. 2006 Jun 30;281(26):18059-68.
REF 8 Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):E636-45.
REF 9 A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. Cancer Cell. 2010 Feb 17;17(2):198-212.

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