Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T87206 Target Info
Target Name S100 calcium-binding protein B (S100B)
Synonyms S-100 protein subunit beta; S-100 protein beta chain; Protein S100-B
Target Type Clinical trial Target
Gene Name S100B
Biochemical Class S100 calcium-binding protein
UniProt ID
S100B_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 3 Auxiliary transporters +
Interacting Protein Name Protein S100-A1 (S100A1) Interacting Protein Interacting Protein Info
UniProt ID
S10A1_HUMAN 
Synonyms S100; S100.alpha; S100A
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Yeast two hybrid [1]
3 Yeast two hybrid [2]
4 Yeast two hybrid [3]
5 Yeast two hybrid [4]
Interacting Target Name S100 calcium-binding protein A6 (S100A6) Literature-reported Target Interacting Protein Info
UniProt ID
S10A6_HUMAN 
Synonyms Protein S100-A6; Prolactin receptor-associated protein; PRA; MLN 4; Growth factor-inducible protein 2A9; Calcyclin; CACY
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [4]
3 Yeast two hybrid [1]
4 Yeast two hybrid [4]
Interacting Protein Name Protein S100-P (S100P) Interacting Protein Interacting Protein Info
UniProt ID
S100P_HUMAN 
Synonyms MIG9
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Yeast two hybrid [6]
References  Top
REF 1 S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo. J Biol Chem. 2000 Nov 10;275(45):35302-10.
REF 2 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell. 2016 Feb 11;164(4):805-17.
REF 3 Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol Syst Biol. 2016 Apr 22;12(4):863.
REF 4 Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma. Exp Cell Res. 1999 Feb 1;246(2):501-9.
REF 5 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 6 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.

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