Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T86399 Target Info
Target Name Bromodomain-containing protein 2 (BRD2)
Synonyms Really interesting new gene 3 protein; RING3; O27.1.1; KIAA9001
Target Type Clinical trial Target
Gene Name BRD2
Biochemical Class Bromodomain
UniProt ID
BRD2_HUMAN 
Target Interacting Proteins  Top
Histones [+] 1 Histones +
Interacting Protein Name Histone H4 (H4) Interacting Protein Interacting Protein Info
UniProt ID
H4_HUMAN 
Synonyms H4FA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Fluorescence Resonance Energy Transfer [2]
3 Reconstituted Complex [3]
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name E2F transcription factor 1 (E2F1) Clinical trial Target Interacting Protein Info
UniProt ID
E2F1_HUMAN 
Synonyms Transcription factor E2F1; Retinoblastoma-binding protein 3; Retinoblastoma-associated protein 1; RBBP-3; RBBP3; RBAP-1; pRB-binding protein E2F-1; PBR3; E2F-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Co-purification [5]
Interacting Target Name Transcription factor E2F2 (E2F2) Literature-reported Target Interacting Protein Info
UniProt ID
E2F2_HUMAN 
Synonyms E2F-2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Co-purification [5]
References  Top
REF 1 Selective recognition of acetylated histones by bromodomain proteins visualized in living cells. Mol Cell. 2004 Jan 16;13(1):33-43.
REF 2 Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation. Cell. 2009 Sep 18;138(6):1122-36.
REF 3 Crystal structure of the human BRD2 bromodomain: insights into dimerization and recognition of acetylated histone H4. J Biol Chem. 2007 Feb 9;282(6):4193-201.
REF 4 Brd2 is a TBP-associated protein and recruits TBP into E2F-1 transcriptional complex in response to serum stimulation. Mol Cell Biochem. 2007 Jan;294(1-2):45-54.
REF 5 RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F. Cell Growth Differ. 2000 Aug;11(8):417-24.
REF 6 Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein. Mol Endocrinol. 2002 Aug;16(8):1727-37.

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