Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T85746 Target Info
Target Name Osteoclast differentiation factor receptor (ODFR)
Synonyms Tumor necrosis factor receptor superfamily member 11A; Receptor activator of NF-KB; RANK; ODFR; CD265
Target Type Literature-reported Target
Gene Name TNFRSF11A
UniProt ID
TNR11_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 3 Acyltransferases +
Interacting Target Name TNF receptor-associated factor 6 (TRAF6) Literature-reported Target Interacting Protein Info
UniProt ID
TRAF6_HUMAN 
Synonyms RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Interacting Protein Name TNF receptor-associated factor 2 (TRAF2) Interacting Protein Interacting Protein Info
UniProt ID
TRAF2_HUMAN 
Synonyms MGC:45012; TRAP; TRAP3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Reconstituted Complex [2]
Interacting Protein Name TNF receptor-associated factor 3 (TRAF3) Interacting Protein Interacting Protein Info
UniProt ID
TRAF3_HUMAN 
Synonyms CAP.1; CAP1; CD40bp; CRAF1; IIAE5; LAP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [4]
Adapter proteins [+] 2 Adapter proteins +
Interacting Protein Name TNF receptor-associated factor 1 (TRAF1) Interacting Protein Interacting Protein Info
UniProt ID
TRAF1_HUMAN 
Synonyms EBI6; MGC:10353
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [4]
Interacting Protein Name TNF receptor-associated factor 5 (TRAF5) Interacting Protein Interacting Protein Info
UniProt ID
TRAF5_HUMAN 
Synonyms MGC:39780; RNF84
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Reconstituted Complex [2]
References  Top
REF 1 Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol Cell Biol. 2002 Feb;22(4):992-1000.
REF 2 Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. J Biol Chem. 1998 Aug 7;273(32):20551-5.
REF 3 Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase. FEBS Lett. 1999 Jan 29;443(3):297-302.
REF 4 The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. J Biol Chem. 1998 Dec 18;273(51):34120-7.
REF 5 The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor. J Biol Chem. 1998 Oct 23;273(43):28355-9.

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