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| Target General Information |
Top |
| Target ID |
T85670 |
Target Info
|
| Target Name |
Nerve growth factor (NGF) |
| Synonyms |
NGFB; Beta-nerve growth factor; Beta-NGF |
| Target Type |
Clinical trial Target |
| Gene Name |
NGF |
| Biochemical Class |
Growth factor |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Kinases |
[+] 1 Kinases |
+ |
| Interacting Target Name |
Tropomyosin-related kinase A (TrkA) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Tyrosine kinase receptor A; Tyrosine kinase receptor; Trk-A; TRKA; TRK1-transforming tyrosine kinase protein; TRK1 transforming tyrosinekinase protein; TRK; P140-TrkA; NGF-trk receptor type A; Neurotrophic tyrosine kinase receptor type 1; MTC; High affinity nerve growth factor receptor; gp140trk |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Co-crystal Structure |
[1] |
| 2 |
Reconstituted Complex |
[2] |
| 3 |
Reconstituted Complex |
[3] |
| References |
Top |
| REF 1 |
Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5. Structure. 2001 Dec;9(12):1191-9.
|
| REF 2 |
Sortilin is essential for proNGF-induced neuronal cell death. Nature. 2004 Feb 26;427(6977):843-8.
|
| REF 3 |
Regulation of cell survival by secreted proneurotrophins. Science. 2001 Nov 30;294(5548):1945-8.
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