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| Target General Information |
Top |
| Target ID |
T84671 |
Target Info
|
| Target Name |
T-cell leukemia/lymphoma protein 1A (TCL1A) |
| Synonyms |
TCL1 oncogene; TCL1; TCL-1 protein; T-cell leukemia/lymphoma 1 oncogene; Protein p14 TCL1; P14 TCL1 protein; Oncogene TCL1; Oncogene TCL-1 |
| Target Type |
Literature-reported Target |
| Gene Name |
TCL1A |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Kinases |
[+] 1 Kinases |
+ |
| Interacting Target Name |
RAC-alpha serine/threonine-protein kinase (AKT1) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB |
| Evidence Score (E-score) |
4 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Affinity Capture-Western |
[2] |
| 3 |
Reconstituted Complex |
[2] |
| 4 |
Yeast two hybrid |
[3] |
| References |
Top |
| REF 1 |
Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. J Biol Chem. 2002 Feb 1;277(5):3743-51.
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| REF 2 |
A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane. Biochemistry. 2002 May 21;41(20):6376-82.
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| REF 3 |
Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. BMC Cancer. 2016 May 26;16:335.
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