Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T83687 Target Info
Target Name B-cell-activating factor receptor (TNFRSF13C)
Synonyms Tumor necrosis factor receptor superfamily member 13C; CD268; BR3; BLyS receptor 3; BAFFR; BAFF-R; BAFF receptor; B cell-activating factor receptor
Target Type Clinical trial Target
Gene Name TNFRSF13C
Biochemical Class Cytokine receptor
UniProt ID
TR13C_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name TNF receptor-associated factor 3 (TRAF3) Interacting Protein Interacting Protein Info
UniProt ID
TRAF3_HUMAN 
Synonyms CAP.1; CAP1; CD40bp; CRAF1; IIAE5; LAP1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Co-crystal Structure [2]
Other proteins [+] 1 Other proteins +
Interacting Target Name B-cell-activating factor (TNFSF13B) Successful Target Interacting Protein Info
UniProt ID
TN13B_HUMAN 
Synonyms ZTNF4; UNQ401/PRO738; Tumor necrosis factor ligand superfamily member 13B; TNFSF20; TNF-and APOL-related leukocyte expressed ligand 1; TNF- and APOL-related leukocyte expressed ligand 1; TALL-1; TALL1; Dendritic cell-derived TNF-like molecule; CD257; BLyS; BAFF; B lymphocyte stimulator; B cell-activating factor
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-crystal Structure [4]
2 Co-localization [5]
References  Top
REF 1 TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production. J Immunol. 2002 Dec 15;169(12):6883-9.
REF 2 Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation. J Immunol. 2004 Dec 15;173(12):7394-400.
REF 3 A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling. J Exp Med. 2010 Nov 22;207(12):2569-79.
REF 4 Ligand-receptor binding revealed by the TNF family member TALL-1. Nature. 2003 May 1;423(6935):49-56.
REF 5 Antibody deficiency associated with an inherited autosomal dominant mutation in TWEAK. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5127-32.

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