Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T81916 Target Info
Target Name Kruppel like factor 4 (KLF4)
Synonyms Krueppellike factor 4; Krueppel-like factor 4; Gutenriched krueppellike factor; Gut-enriched krueppel-like factor; GKLF; Epithelial zinc finger protein EZF; EZF
Target Type Clinical trial Target
Gene Name KLF4
UniProt ID
KLF4_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-localization [2]
3 Reconstituted Complex [3]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 2 (HDAC2) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC2_HUMAN 
Synonyms HD2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [1]
3 Reconstituted Complex [4]
4 Reconstituted Complex [5]
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Biochemical Activity [7]
3 Co-localization [2]
4 Reconstituted Complex [6]
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Co-localization [8]
3 Reconstituted Complex [9]
References  Top
REF 1 ATRA activates and PDGF-BB represses the SM22 promoter through KLF4 binding to, or dissociating from, its cis-DNA elements. Cardiovasc Res. 2011 Jun 1;90(3):464-74.
REF 2 Endothelial cell activation by antiphospholipid antibodies is modulated by Kruppel-like transcription factors. Blood. 2011 Jun 9;117(23):6383-91.
REF 3 Krpel-like factor 4 interacts with p300 to activate mitofusin 2 gene expression induced by all-trans retinoic acid in VSMCs. Acta Pharmacol Sin. 2010 Oct;31(10):1293-302.
REF 4 All-trans retinoic acid increases KLF4 acetylation by inducing HDAC2 phosphorylation and its dissociation from KLF4 in vascular smooth muscle cells. Biochem Biophys Res Commun. 2009 Sep 11;387(1):13-8.
REF 5 The leukocyte integrin gene CD11d is repressed by gut-enriched Kruppel-like factor 4 in myeloid cells. J Biol Chem. 2005 Feb 4;280(5):3449-57.
REF 6 Transactivation and growth suppression by the gut-enriched Krpel-like factor (Krpel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction. Nucleic Acids Res. 2000 Mar 1;28(5):1106-13.
REF 7 Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation. J Biol Chem. 2007 Nov 23;282(47):33994-4002.
REF 8 TGF-1 downregulates AT1 receptor expression via PKC--mediated Sp1 dissociation from KLF4 and Smad-mediated PPAR- association with KLF4. Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):1015-23.
REF 9 The gut-enriched Krpel-like factor suppresses the activity of the CYP1A1 promoter in an Sp1-dependent fashion. J Biol Chem. 1998 Jul 10;273(28):17917-25.

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