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| Target General Information |
Top |
| Target ID |
T81623 |
Target Info
|
| Target Name |
Death-associated protein kinase 3 (DAPK3) |
| Synonyms |
Zipper-interacting protein kinase; ZIPK; ZIP-kinase; MYPT1 kinase; DAP-like kinase; DAP kinase 3 |
| Target Type |
Literature-reported Target |
| Gene Name |
DAPK3 |
| Biochemical Class |
Kinase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Ubiquitin related proteins |
[+] 1 Ubiquitin related proteins |
+ |
| Interacting Target Name |
Ubiquitin-protein ligase E3 Mdm2 (MDM2) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Biochemical Activity |
[1] |
| 2 |
Co-localization |
[2] |
| Other proteins |
[+] 1 Other proteins |
+ |
| Interacting Protein Name |
PRKC apoptosis WT1 regulator protein (PAWR) |
Interacting Protein |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
PAR4; Par.4 |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Biochemical Activity |
[3] |
| 2 |
Biochemical Activity |
[1] |
| 3 |
Yeast two hybrid |
[3] |
| References |
Top |
| REF 1 |
Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1. J Mol Biol. 2004 Mar 12;337(1):115-28.
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| REF 2 |
Zipper-interacting protein kinase is involved in regulation of ubiquitination of the androgen receptor, thereby contributing to dynamic transcription complex assembly. Oncogene. 2013 Oct 10;32(41):4981-8.
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| REF 3 |
ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. Mol Cell Biol. 2003 Sep;23(17):6174-86.
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