Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T81311 Target Info
Target Name Endoplasmin (HSP90B1)
Synonyms gp96 homolog; Tumor rejection antigen 1; TRA1; Heat shock protein 90 kDa beta member 1; GRP94; GRP-94; 94 kDa glucoseregulated protein; 94 kDa glucose-regulated protein
Target Type Clinical trial Target
Gene Name HSP90B1
Biochemical Class Heat shock protein
UniProt ID
ENPL_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Target Name Endoplasmic reticulum chaperone BiP (HSPA5) Clinical trial Target Interacting Protein Info
UniProt ID
BIP_HUMAN 
Synonyms Immunoglobulin heavy chain-binding protein; Immunoglobulin heavy chainbinding protein; HSP70 family protein 5; Heat shock protein family A member 5; Heat shock protein 70 family protein 5; Heat shock 70 kDa protein 5; GRP-78; GRP78; Endoplasmic reticulum lumenal Ca(2+)binding protein grp78; BiP; Binding-immunoglobulin protein; 78 kDa glucose-regulated protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Cellular inhibitor of apoptosis 1 (BIRC2) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC2_HUMAN 
Synonyms TNFR2-TRAF-signaling complex protein 2; TNFR2TRAFsignaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; hIAP-2; hIAP2; C-IAP1; CIAP1; Baculoviral IAP repeat-containing protein 2; Baculoviral IAP repeatcontaining protein 2; API1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Fluorescence Resonance Energy Transfer [3]
4 Fluorescence Resonance Energy Transfer [4]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name Protein OS-9 (OS9) Interacting Protein Interacting Protein Info
UniProt ID
OS9_HUMAN 
Synonyms ERLEC2; OS.9
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [5]
3 Fluorescence Resonance Energy Transfer [6]
Kinases [+] 1 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Protein-Fragment Complementation Assay [8]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [10]
References  Top
REF 1 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 2 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 3 Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation. Cell Death Differ. 2008 May;15(5):859-66.
REF 4 Interaction of heat-shock protein 90 isoform (HSP90) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation. Cell Death Differ. 2008 Feb 1. doi: 10.1038/sj.cdd.4402320.
REF 5 OS-9 facilitates turnover of nonnative GRP94 marked by hyperglycosylation. Mol Biol Cell. 2014 Aug 1;25(15):2220-34.
REF 6 The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9. PLoS One. 2011 Apr 29;6(4):e19151.
REF 7 Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII. J Biol Chem. 2003 Feb 14;278(7):5292-9.
REF 8 Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. Sci Signal. 2009 Dec 22;2(102):ra84.
REF 9 Heat shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver cancer. Cancer Lett. 2015 Apr 10;359(2):325-34.
REF 10 A comprehensive resource of interacting protein regions for refining human transcription factor networks. PLoS One. 2010 Feb 24;5(2):e9289.

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