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| Target General Information |
Top |
| Target ID |
T78932 |
Target Info
|
| Target Name |
TYK2 tyrosine kinase (TYK2) |
| Synonyms |
Non-receptor tyrosine-protein kinase TYK2 |
| Target Type |
Successful Target |
| Gene Name |
TYK2 |
| Biochemical Class |
Kinase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Auxiliary transporters |
[+] 1 Auxiliary transporters |
+ |
| Interacting Target Name |
Interferon alpha/beta receptor 1 (IFNAR1) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Type I interferon receptor 1; IFN-R-1; IFNR1; IFNAR; IFN-alpha/beta receptor 1; IFNalpha/beta receptor 1; Cytokine receptor family 2 member 1; Cytokine receptor class-II member 1; Cytokine receptor classII member 1; CRF2-1; CRF21 |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Reconstituted Complex |
[2] |
| References |
Top |
| REF 1 |
Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif. J Biol Chem. 2008 Jul 4;283(27):18566-72.
|
| REF 2 |
Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem. 1998 Sep 18;273(38):24723-9.
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