Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T78492 Target Info
Target Name MAPK/ERK kinase kinase 4 (MAP3K4)
Synonyms Mitogen-activated protein kinase kinase kinase 4; MTK1; MEKK4; MEKK 4; MEK kinase 4; MAPKKK4; MAP three kinase 1; KIAA0213
Target Type Literature-reported Target
Gene Name MAP3K4
Biochemical Class Kinase
UniProt ID
M3K4_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 1 Kinases +
Interacting Protein Name Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) Interacting Protein Interacting Protein Info
UniProt ID
MP2K3_HUMAN 
Synonyms MAPKK3; MEK3; MKK3; PRKMK3; SAPKK.2; SAPKK2
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [1]
2 Reconstituted Complex [2]
Other proteins [+] 1 Other proteins +
Interacting Target Name Negative growth-regulatory protein MyD118 (GADD45B) Literature-reported Target Interacting Protein Info
UniProt ID
GA45B_HUMAN 
Synonyms Negative growth-regulatory protein MyD118; Myeloid differentiation primary response protein MyD118; GADD45beta; GADD45B; DNA damage-inducible gene 45beta
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Yeast two hybrid [3]
References  Top
REF 1 Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades. Biochem J. 1998 Dec 15;336 ( Pt 3):599-609.
REF 2 Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases. Mol Cell. 2005 Apr 29;18(3):295-306.
REF 3 A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell. 1998 Nov 13;95(4):521-30.
REF 4 CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway. Biochem Biophys Res Commun. 2005 Dec 16;338(2):808-14.

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