Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T78429 Target Info
Target Name Inhibitor of nuclear factor kappa-B kinase beta (IKKB)
Synonyms Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; IkBKB; IKKB; IKK2; IKK-beta; IKK-B; I-kappa-B-kinase beta; I-kappa-B kinase 2
Target Type Clinical trial Target
Gene Name IKBKB
Biochemical Class Kinase
UniProt ID
IKKB_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 3 Acyltransferases +
Interacting Protein Name TNF receptor-associated factor 2 (TRAF2) Interacting Protein Interacting Protein Info
UniProt ID
TRAF2_HUMAN 
Synonyms MGC:45012; TRAP; TRAP3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Co-localization [3]
4 Reconstituted Complex [4]
Interacting Target Name Nuclear receptor coactivator 3 (NCOA3) Literature-reported Target Interacting Protein Info
UniProt ID
NCOA3_HUMAN 
Synonyms TRAM-1; TRAM1; Thyroid hormone receptor activator molecule 1; Steroid receptor coactivator protein 3; SRC-3; Receptor-associated coactivator 3; RAC-3; RAC3; PCIP; NCoA-3; Class E basic helix-loop-helix protein 42; CBP-interacting protein; bHLHe42; Amplified in breast cancer-1 protein; Amplified in breast cancer 1 protein; AIB1 (SRC-3); AIB-1; AIB1; ACTR
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [6]
3 Co-fractionation [6]
Interacting Target Name Zinc finger protein A20 (TNFAIP3) Literature-reported Target Interacting Protein Info
UniProt ID
TNAP3_HUMAN 
Synonyms Tumor necrosis factor, alpha-induced protein3; Tumor necrosis factor alpha-induced protein 3; TNF alpha-induced protein 3; Putative DNA-binding protein A20; Putative DNA binding protein A20; OTUD7C; OTU domain-containing protein 7C; A20
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Biochemical Activity [8]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name TNF receptor-associated factor 1 (TRAF1) Interacting Protein Interacting Protein Info
UniProt ID
TRAF1_HUMAN 
Synonyms EBI6; MGC:10353
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Fluorescence Resonance Energy Transfer [9]
3 Yeast two hybrid [9]
4 Yeast two hybrid [10]
Cell division cycle proteins [+] 1 Cell division cycle proteins +
Interacting Target Name Hsp90 co-chaperone Cdc37 (CDC37) Literature-reported Target Interacting Protein Info
UniProt ID
CDC37_HUMAN 
Synonyms p50Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed; Hsp90 chaperone protein kinase-targeting subunit; CDC37A
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Co-purification [12]
3 Reconstituted Complex [12]
COP9 signalosomes [+] 1 COP9 signalosomes +
Interacting Protein Name COP9 signalosome complex subunit 3 (COPS3) Interacting Protein Interacting Protein Info
UniProt ID
CSN3_HUMAN 
Synonyms CSN3; SGN3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Affinity Capture-Western [14]
3 Yeast two hybrid [13]
Cytokine receptors [+] 1 Cytokine receptors +
Interacting Target Name GMCSFR-alpha (CSF2RA) Successful Target Interacting Protein Info
UniProt ID
CSF2R_HUMAN 
Synonyms GMR; GM-CSF-R-alpha; GM-CSFR; CSF2RA; CDw116; CD116 antigen
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-localization [3]
2 Fluorescence Resonance Energy Transfer [15]
3 Reconstituted Complex [15]
Kinases [+] 6 Kinases +
Interacting Target Name Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) Literature-reported Target Interacting Protein Info
UniProt ID
IKKA_HUMAN 
Synonyms Transcription factor 16; TCF-16; TCF16; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; NFKBIKA; Inhibitory kappa B kinasea; Inhibitor of nuclear factor kappa-B kinase subunit alpha; IKK-alpha; IKK-A; IKK1; IkBKA; I-kappa-B kinase alpha; I-kappa-B kinase 1; IkappaB kinase; I kappa-B kinase alpha; Conserved helix-loop-helix ubiquitous kinase
Evidence Score (E-score) 16 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Affinity Capture-MS [17]
3 Affinity Capture-MS [11]
4 Affinity Capture-Western [18]
5 Affinity Capture-Western [19]
6 Affinity Capture-Western [20]
7 Affinity Capture-Western [21]
8 Affinity Capture-Western [22]
9 Affinity Capture-Western [23]
10 Affinity Capture-Western [24]
11 Biochemical Activity [25]
12 Co-fractionation [26]
13 Co-localization [3]
14 Co-purification [27]
15 Co-purification [12]
16 Reconstituted Complex [28]
Interacting Target Name Serine/threonine-protein kinase NIK (MAP3K14) Literature-reported Target Interacting Protein Info
UniProt ID
M3K14_HUMAN 
Synonyms NIK; NF-kappa-beta-inducing kinase; Mitogen-activated protein kinase kinase kinase 14; HsNIK
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Biochemical Activity [22]
3 Reconstituted Complex [29]
Interacting Target Name Proto-oncogene c-Src (SRC) Successful Target Interacting Protein Info
UniProt ID
SRC_HUMAN 
Synonyms Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Biochemical Activity [31]
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [32]
2 Co-localization [3]
Interacting Target Name Receptor-interacting protein 1 (RIPK1) Clinical trial Target Interacting Protein Info
UniProt ID
RIPK1_HUMAN 
Synonyms RIP-1; RIP1; RIP; Receptor-interacting serine/threonine-protein kinase 1; Cell death protein RIP
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-fractionation [33]
2 Reconstituted Complex [34]
Interacting Target Name TGF-beta-activated kinase 1 (MAP3K7) Literature-reported Target Interacting Protein Info
UniProt ID
M3K7_HUMAN 
Synonyms Transforming growth factor-beta-activated kinase 1; TAK1; Mitogen-activated protein kinase kinase kinase 7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [35]
2 Biochemical Activity [21]
Peptidases [+] 1 Peptidases +
Interacting Target Name JUN activation domain binding protein (COPS5) Literature-reported Target Interacting Protein Info
UniProt ID
CSN5_HUMAN 
Synonyms Signalosome subunit 5; SGN5; Jun activation domain-binding protein 1; JAB1; CSN5; COP9 signalosome complex subunit 5
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Affinity Capture-Western [14]
3 Biochemical Activity [13]
4 Fluorescence Resonance Energy Transfer [13]
5 Yeast two hybrid [13]
Transcription regulators [+] 4 Transcription regulators +
Interacting Target Name DNA-binding factor KBF1 (p105) Clinical trial Target Interacting Protein Info
UniProt ID
NFKB1_HUMAN 
Synonyms Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; Nuclear factor of kappa light polypeptide gene enhancer in Bcells 1; Nuclear factor NFkappaB p50 subunit; Nuclear factor NF-kappa-B p105 subunit; Nuclear factor NFkappaB p105 subunit; EBP-1; EBP1; DNA-binding factor KBF1; DNAbinding factor KBF1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [36]
2 Biochemical Activity [37]
3 Biochemical Activity [36]
4 Co-localization [3]
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 4 Experimental Evidences +
1 Biochemical Activity [38]
2 Biochemical Activity [39]
3 Biochemical Activity [40]
4 Co-localization [3]
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [41]
2 Co-localization [3]
Interacting Protein Name Forkhead box protein O3 (FOXO3) Interacting Protein Interacting Protein Info
UniProt ID
FOXO3_HUMAN 
Synonyms AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [42]
2 Co-localization [3]
Other proteins [+] 5 Other proteins +
Interacting Protein Name NF-kappa-B inhibitor alpha (NFKBIA) Interacting Protein Interacting Protein Info
UniProt ID
IKBA_HUMAN 
Synonyms IKBA; MAD.3; NFKBI
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-Western [43]
2 Affinity Capture-Western [44]
3 Affinity Capture-Western [45]
4 Affinity Capture-Western [46]
5 Affinity Capture-Western [2]
6 Biochemical Activity [19]
7 Biochemical Activity [47]
8 Biochemical Activity [48]
9 Biochemical Activity [49]
10 Biochemical Activity [50]
11 Biochemical Activity [51]
12 Biochemical Activity [52]
13 Biochemical Activity [26]
14 Biochemical Activity [53]
15 Biochemical Activity [54]
16 Biochemical Activity [55]
17 Biochemical Activity [56]
18 Biochemical Activity [57]
19 Biochemical Activity [22]
20 Biochemical Activity [58]
Interacting Protein Name NF-kappa-B essential modulator (IKBKG) Interacting Protein Interacting Protein Info
UniProt ID
NEMO_HUMAN 
Synonyms AMCBX1; FIP.3; FIP3; Fip3p; IKK.gamma; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-MS [17]
3 Affinity Capture-Western [59]
4 Affinity Capture-Western [49]
5 Affinity Capture-Western [60]
6 Affinity Capture-Western [61]
7 Affinity Capture-Western [62]
8 Affinity Capture-Western [63]
9 Affinity Capture-Western [6]
10 Affinity Capture-Western [21]
11 Affinity Capture-Western [24]
12 Affinity Capture-Western [64]
13 Affinity Capture-Western [65]
14 Affinity Capture-Western [66]
15 Affinity Capture-Western [67]
16 Biochemical Activity [68]
17 Co-fractionation [65]
18 Co-fractionation [69]
19 Co-purification [70]
20 Co-purification [12]
Interacting Target Name Tumor necrosis factor receptor type I (TNF-R1) Clinical trial Target Interacting Protein Info
UniProt ID
TNR1A_HUMAN 
Synonyms Tumor necrosis factor-binding protein 1; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-RI; TNFR-I; TNFR1; TNFAR; TBPI; p60; p55; CD120a
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [71]
2 Biochemical Activity [72]
3 Co-localization [3]
4 Reconstituted Complex [72]
Interacting Protein Name NF-kappa-B inhibitor beta (NFKBIB) Interacting Protein Interacting Protein Info
UniProt ID
IKBB_HUMAN 
Synonyms IKBB; TRIP9
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Biochemical Activity [19]
3 Biochemical Activity [54]
Interacting Target Name Tumor necrosis factor (TNF) Successful Target Interacting Protein Info
UniProt ID
TNFA_HUMAN 
Synonyms Tumour necrosis factor alpha; Tumour necrosis factor; Tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor; TNFSF2; TNF-alpha; TNFalpha; TNF-a; TNFA; TNF alpha; Cachectin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [73]
2 Affinity Capture-Western [74]
References  Top
REF 1 Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1. Nat Immunol. 2008 May;9(5):533-41.
REF 2 Kelch-like Protein 21 (KLHL21) Targets IB Kinase- to Regulate Nuclear Factor -Light Chain Enhancer of Activated B Cells (NF-B) Signaling Negatively. J Biol Chem. 2016 Aug 26;291(35):18176-89.
REF 3 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 4 PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination. Mol Cell. 2009 Jan 16;33(1):30-42.
REF 5 Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. Mol Endocrinol. 2005 Oct;19(10):2451-65.
REF 6 Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase. Mol Cell Biol. 2002 May;22(10):3549-61.
REF 7 Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression. J Biol Chem. 2011 Mar 11;286(10):7905-16.
REF 8 A20 inhibits NF-kappa B activation downstream of multiple Map3 kinases and interacts with the I kappa B signalosome. Cytokine. 2001 Sep 21;15(6):282-98.
REF 9 Interaction of the TNFR-receptor associated factor TRAF1 with I-kappa B kinase-2 and TRAF2 indicates a regulatory function for NF-kappa B signaling. PLoS One. 2010 Sep 13;5(9):e12683.
REF 10 Caspase-mediated cleavage converts the tumor necrosis factor (TNF) receptor-associated factor (TRAF)-1 from a selective modulator of TNF receptor signaling to a general inhibitor of NF-kappaB activation. J Biol Chem. 2003 Aug 1;278(31):29216-30.
REF 11 Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity. 2011 Sep 23;35(3):426-40.
REF 12 TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. Mol Cell. 2002 Feb;9(2):401-10.
REF 13 Crosstalk between the NF-kappaB activating IKK-complex and the CSN signalosome. J Cell Mol Med. 2010 Jun;14(6B):1555-68.
REF 14 Endothelial CSN5 impairs NF-B activation and monocyte adhesion to endothelial cells and is highly expressed in human atherosclerotic lesions. Thromb Haemost. 2013 Jul;110(1):141-52.
REF 15 GMCSF activates NF-kappaB via direct interaction of the GMCSF receptor with IkappaB kinase beta. Blood. 2003 Jul 1;102(1):192-9.
REF 16 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 17 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Sci Signal. 2015 Apr 7;8(371):rs3.
REF 18 The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell. 1997 Oct 17;91(2):243-52.
REF 19 IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science. 1997 Oct 31;278(5339):866-9.
REF 20 IB kinases increase Myc protein stability and enhance progression of breast cancer cells. Mol Cancer. 2011 May 16;10:53.
REF 21 ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress. Mol Cell. 2010 Oct 8;40(1):75-86.
REF 22 Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase. J Biol Chem. 2006 Jan 20;281(3):1495-505.
REF 23 Characterization of the Ikappa B-kinase NEMO binding domain. J Biol Chem. 2002 Nov 29;277(48):45992-6000.
REF 24 IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell. 2007 Aug 10;130(3):440-55.
REF 25 Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation. Mol Cell Biol. 2001 Nov;21(21):7207-17.
REF 26 Role of IKKgamma/nemo in assembly of the Ikappa B kinase complex. J Biol Chem. 2001 Feb 9;276(6):4494-500.
REF 27 Fanconi anemia protein complex is a novel target of the IKK signalsome. J Cell Biochem. 2002;86(4):613-23.
REF 28 IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science. 1997 Oct 31;278(5339):860-6.
REF 29 Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40. J Biol Chem. 2001 May 4;276(18):14602-6.
REF 30 c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression. J Biol Chem. 2003 Mar 14;278(11):9944-52.
REF 31 Induction of cyclooxygenase-2 overexpression in human gastric epithelial cells by Helicobacter pylori involves TLR2/TLR9 and c-Src-dependent nuclear factor-kappaB activation. Mol Pharmacol. 2004 Dec;66(6):1465-77.
REF 32 The antiapoptotic effect of fibroblast growth factor-2 is mediated through nuclear factor-kappaB activation induced via interaction between Akt and IkappaB kinase-beta in breast cancer cells. Oncogene. 2005 Aug 18;24(35):5482-91.
REF 33 A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage. Mol Cell Biol. 2011 Jul;31(14):2774-86.
REF 34 Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization. J Biol Chem. 2000 Dec 1;275(48):37966-77.
REF 35 Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression. Cancer Res. 2008 Mar 1;68(5):1462-70.
REF 36 The death domain of NF-kappa B1 p105 is essential for signal-induced p105 proteolysis. J Biol Chem. 2002 Jul 5;277(27):24162-8.
REF 37 Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha. Mol Cell Biol. 2001 Feb;21(4):1024-35.
REF 38 Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription. J Biol Chem. 2004 Dec 31;279(53):55633-43.
REF 39 Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev. 2008 Jun 1;22(11):1490-500.
REF 40 IKKbeta phosphorylates p65 at S468 in transactivaton domain 2. FASEB J. 2005 Oct;19(12):1758-60.
REF 41 Nuclear role of I kappa B Kinase-gamma/NF-kappa B essential modulator (IKK gamma/NEMO) in NF-kappa B-dependent gene expression. J Biol Chem. 2004 Jan 30;279(5):3509-15.
REF 42 IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell. 2004 Apr 16;117(2):225-37.
REF 43 Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit. Science. 2004 Jun 25;304(5679):1963-7.
REF 44 Hepatitis B virus polymerase suppresses NF-B signaling by inhibiting the activity of IKKs via interaction with Hsp90. PLoS One. 2014 Mar 11;9(3):e91658.
REF 45 Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation. Mol Cell. 2010 Aug 27;39(4):570-82.
REF 46 Role of monoubiquitylation on the control of IB degradation and NF-B activity. PLoS One. 2011;6(10):e25397.
REF 47 Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways. Mol Cell. 2004 May 7;14(3):303-17.
REF 48 The IKK complex contributes to the induction of autophagy. EMBO J. 2010 Feb 3;29(3):619-31.
REF 49 p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO. Nat Commun. 2012;3:1061.
REF 50 Competition between TRAF2 and TRAF6 regulates NF-kappaB activation in human B lymphocytes. Chin Med Sci J. 2010 Mar;25(1):1-12.
REF 51 Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. Science. 1998 Aug 28;281(5381):1360-3.
REF 52 All three IkappaB isoforms and most Rel family members are stably associated with the IkappaB kinase 1/2 complex. Eur J Biochem. 1999 Jan;259(1-2):253-61.
REF 53 The catalytic subunits of IkappaB kinase, IKK-1 and IKK-2, contain non-equivalent active sites when expressed as homodimers. Biochem Biophys Res Commun. 2002 May 24;293(5):1508-13.
REF 54 MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9319-24.
REF 55 Tumor necrosis factor receptor-associated factor 1 gene overexpression in B-cell chronic lymphocytic leukemia: analysis of NF-kappa B/Rel-regulated inhibitors of apoptosis. Blood. 2002 Nov 15;100(10):3749-56.
REF 56 Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways. EMBO J. 2007 Apr 4;26(7):1794-805.
REF 57 NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell. 2010 Apr 30;141(3):483-96.
REF 58 Binding of manumycin A inhibits IkappaB kinase beta activity. J Biol Chem. 2006 Feb 3;281(5):2551-61.
REF 59 SHARPIN is a component of the NF-B-activating linear ubiquitin chain assembly complex. Nature. 2011 Mar 31;471(7340):633-6.
REF 60 The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways. J Exp Med. 2002 Dec 16;196(12):1605-15.
REF 61 Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation. Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18279-84.
REF 62 A novel pVHL-independent but NEMO-driven pathway in renal cancer promotes HIF stabilization. Oncogene. 2016 Jun 16;35(24):3125-38.
REF 63 Lack of interaction between NEMO and SHARPIN impairs linear ubiquitination and NF-B activation and leads to incontinentia pigmenti. J Allergy Clin Immunol. 2017 Dec;140(6):1671-1682.e2.
REF 64 The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. Nat Immunol. 2009 Nov;10(11):1215-21.
REF 65 MUC1 oncoprotein activates the IkappaB kinase beta complex and constitutive NF-kappaB signalling. Nat Cell Biol. 2007 Dec;9(12):1419-27.
REF 66 PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress. Nat Cell Biol. 2006 Sep;8(9):986-93.
REF 67 LRRC14 attenuates Toll-like receptor-mediated NF-B signaling through disruption of IKK complex. Exp Cell Res. 2016 Sep 10;347(1):65-73.
REF 68 Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity. J Biol Chem. 2008 Jan 4;283(1):76-86.
REF 69 Dimerization of the I kappa B kinase-binding domain of NEMO is required for tumor necrosis factor alpha-induced NF-kappa B activity. Mol Cell Biol. 2006 Dec;26(24):9209-19.
REF 70 Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell. 2000 Oct 13;103(2):351-61.
REF 71 Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. Immunity. 2000 Mar;12(3):301-11.
REF 72 Phospho-SXXE/D motif mediated TNF receptor 1-TRADD death domain complex formation for T cell activation and migration. J Immunol. 2011 Aug 1;187(3):1289-97.
REF 73 Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell. 2009 Dec 11;36(5):831-44.
REF 74 Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell. 2006 Apr 21;22(2):245-57.

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