Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T78319 | Target Info | |||
| Target Name | Extracellular matrix receptor III (CD44) | ||||
| Synonyms | Phagocytic glycoprotein I; Phagocytic glycoprotein 1; PGP-I; PGP-1; MIC4; MDU3; MDU2; LHR; Hyaluronate receptor; Hermes antigen; Heparan sulfate proteoglycan; HUTCH-I; GP90 lymphocyte homing/adhesion receptor; Extracellular matrix receptor-III; Epican; ECMR-III; CDw44; CD44 antigen | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CD44 | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Kinases | [+] 4 Kinases | + | |||
| Interacting Target Name | Proto-oncogene c-Src (SRC) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Co-localization | [3] | |||
| 4 | Reconstituted Complex | [1] | |||
| Interacting Target Name | LCK tyrosine protein kinase (LCK) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Tyrosine-protein kinase Lck; T cell-specific protein-tyrosine kinase; Proto-oncogene tyrosine-protein kinase LCK; Proto-oncogene Lck; Protein YT16; p56-LCK; Lymphocyte cell-specific protein-tyrosine kinase; LSK; Leukocyte C-terminal Src kinase; LCK Protooncogene Syn; LCK p59-Fyn | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [4] | |||
| 2 | Affinity Capture-Western | [5] | |||
| 3 | Co-fractionation | [5] | |||
| Interacting Target Name | Fibroblast growth factor receptor 1 (FGFR1) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | N-sam; HBGFR; Fms-like tyrosine kinase 2; FLT-2; FLT2; FLG; FGFR-1; FGFBR; c-fgr; CEK; CD331 antigen; CD331; bFGF-R-1; bFGF-R; BFGFR; Basic fibroblast growth factor receptor 1 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [6] | |||
| 2 | Affinity Capture-Western | [7] | |||
| Interacting Target Name | TGF-beta receptor type I (TGFBR1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Type I TGFbeta receptor kinase; Transforming growth factor-beta receptor type I; TGFR-1; TGF-beta type I receptor; TGF-beta receptor type-1; TbetaR-I; TbetaRI; SKR4; Serine/threonine-protein kinase receptor R4; ALK-5; ALK5; Activin receptor-like kinase 5; Activin A receptor type II-like protein kinase of 53kD | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [7] | |||
| 2 | Reconstituted Complex | [8] | |||
| Other proteins | [+] 2 Other proteins | + | |||
| Interacting Protein Name | Versican core protein (VCAN) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | CSPG2; ERVR; GHAP; PG.M; WGN; WGN1 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [6] | |||
| 2 | Reconstituted Complex | [9] | |||
| Interacting Protein Name | Neurofibromin-2 (NF2) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | ACN; BANF; SCH | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [10] | |||
| 2 | Protein-peptide | [11] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration. J Biol Chem. 2001 Mar 9;276(10):7327-36. | ||||
| REF 2 | The ankyrin-binding domain of CD44s is involved in regulating hyaluronic acid-mediated functions and prostate tumor cell transformation. Cell Motil Cytoskeleton. 1998;39(3):209-22. | ||||
| REF 3 | Direct reprogramming of stem cell properties in colon cancer cells by CD44. EMBO J. 2011 Jun 24;30(15):3186-99. | ||||
| REF 4 | Signaling through CD44 is mediated by tyrosine kinases. Association with p56lck in T lymphocytes. J Biol Chem. 1996 Feb 2;271(5):2863-7. | ||||
| REF 5 | CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes. Blood. 1998 May 15;91(10):3901-8. | ||||
| REF 6 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
| REF 7 | Bikunin down-regulates heterodimerization between CD44 and growth factor receptors and subsequently suppresses agonist-mediated signaling. J Cell Biochem. 2005 Apr 1;94(5):995-1009. | ||||
| REF 8 | Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor beta receptor I in metastatic breast tumor cells. J Biol Chem. 2002 Oct 18;277(42):39703-12. | ||||
| REF 9 | Binding of a large chondroitin sulfate/dermatan sulfate proteoglycan, versican, to L-selectin, P-selectin, and CD44. J Biol Chem. 2000 Nov 10;275(45):35448-56. | ||||
| REF 10 | Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation. Nat Cell Biol. 2007 Oct;9(10):1199-207. | ||||
| REF 11 | Structural basis of DDB1-and-Cullin 4-associated Factor 1 (DCAF1) recognition by merlin/NF2 and its implication in tumorigenesis by CD44-mediated inhibition of merlin suppression of DCAF1 function. Genes Cells. 2014 Aug;19(8):603-19. | ||||
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