Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T77350 | Target Info | |||
| Target Name | Proteasome beta-8 (PS beta-8) | ||||
| Synonyms | Y2; Really interesting new gene 10 protein; RING10; Proteasome subunit beta-5i; Proteasome subunit beta type-8; Proteasome component C13; PSMB5i; Multicatalytic endopeptidase complex subunit C13; Macropain subunit C13; Low molecular mass protein 7; LMP7 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PSMB8 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Peptidases | [+] 4 Peptidases | + | |||
| Interacting Target Name | Proteasome beta-1 (PS beta-1) | Patented-recorded Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Proteasome subunit Y; Proteasome subunit beta type-6; Proteasome delta chain; Multicatalytic endopeptidase complex delta chain; Macropain delta chain; LMPY | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Co-fractionation | [2] | |||
| 3 | Co-fractionation | [3] | |||
| 4 | Yeast two hybrid | [4] | |||
| Interacting Target Name | Proteasome beta-2 (PS beta-2) | Patented-recorded Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Proteasome subunit Z; Proteasome subunit beta type-7; Multicatalytic endopeptidase complex chain Z; Macropain chain Z | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [5] | |||
| 2 | Co-fractionation | [2] | |||
| 3 | Yeast two hybrid | [4] | |||
| Interacting Protein Name | Proteasome subunit beta type-1 (PSMB1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | HC5; PMSB1; PSC5 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Co-fractionation | [2] | |||
| 2 | Yeast two hybrid | [4] | |||
| Interacting Protein Name | Proteasome subunit beta type-3 (PSMB3) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | HC10.II | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Co-fractionation | [3] | |||
| 2 | Yeast two hybrid | [4] | |||
| Other proteins | [+] 1 Other proteins | + | |||
| Interacting Protein Name | Proteasome maturation protein (POMP) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | C13orf12; PNAS.110; UMP1 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [6] | |||
| 2 | Yeast two hybrid | [6] | |||
| 3 | Yeast two hybrid | [4] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Pronounced up-regulation of the PA28alpha/beta proteasome regulator but little increase in the steady-state content of immunoproteasome during dendritic cell maturation. Eur J Immunol. 2001 Nov;31(11):3271-80. | ||||
| REF 2 | A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9. | ||||
| REF 3 | Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44. | ||||
| REF 4 | The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum. EMBO Rep. 2007 Dec;8(12):1170-5. | ||||
| REF 5 | Tumor cell lines expressing the proteasome subunit isoform LMP7E1 exhibit immunoproteasome deficiency. Cancer Res. 2006 Jan 15;66(2):649-52. | ||||
| REF 6 | IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response. Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9241-6. | ||||
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