Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T76910 Target Info
Target Name Glycogen synthase kinase-3 alpha (GSK-3A)
Synonyms Serine/threonineprotein kinase GSK3A; Serine/threonine-protein kinase GSK3A; Glycogen synthase kinase3 alpha; Glycogen synthase kinase 3; GSK3 alpha; GSK-3 alpha; GSK-3
Target Type Successful Target
Gene Name GSK3A
Biochemical Class Kinase
UniProt ID
GSK3A_HUMAN 
Target Interacting Proteins  Top
Other proteins [+] 4 Other proteins +
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [2]
Interacting Protein Name GSK3B-interacting protein (GSKIP) Interacting Protein Interacting Protein Info
UniProt ID
GSKIP_HUMAN 
Synonyms C14orf129
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Yeast two hybrid [4]
Interacting Protein Name Next to BRCA1 gene 1 protein (NBR1) Interacting Protein Interacting Protein Info
UniProt ID
NBR1_HUMAN 
Synonyms 1A1.3B; IAI3B; M17S2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Biochemical Activity [5]
Interacting Protein Name Spindle and centriole-associated protein 1 (SPICE1) Interacting Protein Interacting Protein Info
UniProt ID
SPICE_HUMAN 
Synonyms CCDC52; SPICE
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
References  Top
REF 1 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 2 Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation. J Biol Chem. 2015 May 29;290(22):14120-9.
REF 3 Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4.
REF 4 Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Mol Cell Proteomics. 2010 Jul;9(7):1578-93.
REF 5 Phosphorylation of NBR1 by GSK3 modulates protein aggregation. Autophagy. 2014 Jun;10(6):1036-53.

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