Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T75419 Target Info
Target Name Fanconi anemia group F protein (FANCF)
Synonyms Protein FACF
Target Type Literature-reported Target
Gene Name FANCF
UniProt ID
FANCF_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase FANCL (FANCL) Interacting Protein Interacting Protein Info
UniProt ID
FANCL_HUMAN 
Synonyms FAAP43; PHF9; POG
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-localization [2]
3 Reconstituted Complex [3]
Other proteins [+] 4 Other proteins +
Interacting Protein Name Fanconi anemia group A protein (FANCA) Interacting Protein Interacting Protein Info
UniProt ID
FANCA_HUMAN 
Synonyms FA; FA.H; FA1; FAA; FACA; FAH; FANCH
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-Luminescence [4]
2 Affinity Capture-Western [5]
3 Affinity Capture-Western [6]
4 Affinity Capture-Western [7]
5 Affinity Capture-Western [8]
6 Affinity Capture-Western [9]
7 Affinity Capture-Western [1]
8 Affinity Capture-Western [10]
9 Reconstituted Complex [3]
10 Yeast two hybrid [5]
Interacting Protein Name Fanconi anemia group G protein (FANCG) Interacting Protein Interacting Protein Info
UniProt ID
FANCG_HUMAN 
Synonyms FAG; XRCC9
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [11]
3 Affinity Capture-Western [9]
4 Affinity Capture-Western [1]
5 Reconstituted Complex [3]
6 Yeast two hybrid [12]
7 Yeast two hybrid [13]
Interacting Protein Name Fanconi anemia group E protein (FANCE) Interacting Protein Interacting Protein Info
UniProt ID
FANCE_HUMAN 
Synonyms FACE; FAE
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [9]
4 Affinity Capture-Western [14]
5 Reconstituted Complex [3]
6 Yeast two hybrid [5]
Interacting Protein Name Fanconi anemia group C protein (FANCC) Interacting Protein Interacting Protein Info
UniProt ID
FANCC_HUMAN 
Synonyms FA3; FAC; FACC
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [9]
3 Reconstituted Complex [3]
References  Top
REF 1 Evidence for subcomplexes in the Fanconi anemia pathway. Blood. 2006 Sep 15;108(6):2072-80.
REF 2 Modularized functions of the Fanconi anemia core complex. Cell Rep. 2014 Jun 26;7(6):1849-57.
REF 3 Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway. Mol Cell. 2017 Jan 19;65(2):247-259.
REF 4 HSP90 Shapes the Consequences of Human Genetic Variation. Cell. 2017 Feb 23;168(5):856-866.e12.
REF 5 The Fanconi anemia gene product FANCF is a flexible adaptor protein. J Biol Chem. 2004 Sep 17;279(38):39421-30.
REF 6 The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG. Hum Mol Genet. 2000 Nov 1;9(18):2665-74.
REF 7 Physical and functional crosstalk between Fanconi anemia core components and the GINS replication complex. DNA Repair (Amst). 2011 Feb 7;10(2):149-58.
REF 8 FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia. Mol Cell. 2009 Dec 25;36(6):943-53.
REF 9 Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex. J Biol Chem. 2007 Jan 19;282(3):2047-55.
REF 10 A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Nat Genet. 2005 Sep;37(9):958-63.
REF 11 Several tetratricopeptide repeat (TPR) motifs of FANCG are required for assembly of the BRCA2/D1-D2-G-X3 complex, FANCD2 monoubiquitylation and phleomycin resistance. Mutat Res. 2010 Jul 7;689(1-2):12-20.
REF 12 Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems. Blood. 2003 Jul 1;102(1):136-41.
REF 13 Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway. Hum Mol Genet. 2001 Feb 15;10(4):423-9.
REF 14 Analysis of a FANCE Splice Isoform in Regard to DNA Repair. J Mol Biol. 2015 Sep 25;427(19):3056-73.

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