Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T72850 Target Info
Target Name Forkhead box protein O1A (FOXO1)
Synonyms Forkhead in rhabdomyosarcoma; Forkhead box protein O1; FOXO1A; FKHR
Target Type Literature-reported Target
Gene Name FOXO1
UniProt ID
FOXO1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [2]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name 14-3-3 protein zeta/delta (YWHAZ) Interacting Protein Interacting Protein Info
UniProt ID
1433Z_HUMAN 
Synonyms 14.3.3.zeta; HEL.S.3; HEL4; KCIP.1; YWHAD
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Fluorescence Resonance Energy Transfer [4]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name NAD-dependent deacetylase sirtuin-2 (SIRT2) Patented-recorded Target Interacting Protein Info
UniProt ID
SIR2_HUMAN 
Synonyms SIR2-like protein 2; SIR2like protein 2; SIR2L2; SIR2L; Regulatory protein SIR2 homolog 2; NAD-dependent protein deacetylase sirtuin-2; NADdependent protein deacetylase sirtuin2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Reconstituted Complex [5]
Kinases [+] 1 Kinases +
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [6]
2 Co-localization [7]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Reconstituted Complex [9]
3 Yeast two hybrid [9]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [10]
3 Reconstituted Complex [5]
4 Yeast two hybrid [11]
Other proteins [+] 1 Other proteins +
Interacting Target Name S-phase kinase-associated protein 2 (SKP2) Literature-reported Target Interacting Protein Info
UniProt ID
SKP2_HUMAN 
Synonyms Skp2; P45skp2; FBXL1; F-box/LRR-repeat protein 1; F-box protein Skp2; Cyclin-A/CDK2-associated protein p45; Cyclin A/CDK2-associated protein p45; Cyclin A/CDK2-associated p45
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Reconstituted Complex [12]
References  Top
REF 1 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol Syst Biol. 2015 Jan 21;11(1):775.
REF 2 The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription. Mol Endocrinol. 2005 Sep;19(9):2283-98.
REF 3 Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting. Biochem J. 2001 Mar 15;354(Pt 3):605-12.
REF 4 OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860.
REF 5 Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10042-7.
REF 6 Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11278-83.
REF 7 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 8 Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells. Oncogene. 2012 Nov 15;31(46):4868-77.
REF 9 Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family. J Biol Chem. 2001 Sep 7;276(36):33554-60.
REF 10 FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab. 2005 Sep;2(3):153-63.
REF 11 DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10412-7.
REF 12 Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1649-54.

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