Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T72038 | Target Info | |||
| Target Name | Galectin-3 (LGALS3) | ||||
| Synonyms | Mac-2 antigen; MAC2; Lectin L-29; Laminin-binding protein; L-31; IgE-binding protein; Galactoside-binding protein; Galactose-specific lectin 3; Gal-3; GALBP; Carbohydrate-binding protein 35; Carbohydrate binding protein 35; CBP 35; Beta-galactoside-binding protein LGALS3; 35 kDa lectin | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | LGALS3 | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Kinases | [+] 1 Kinases | + | |||
| Interacting Target Name | Epidermal growth factor receptor (EGFR) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| Peptidases | [+] 1 Peptidases | + | |||
| Interacting Target Name | Endothelin-converting enzyme 1 (ECE1) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | ECE-1 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [3] | |||
| 2 | Affinity Capture-MS | [4] | |||
| Porters | [+] 1 Porters | + | |||
| Interacting Protein Name | Solute carrier family 12 member 1 (S12A2) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | BSC; BSC2; NKCC1; PPP1R141 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [3] | |||
| 2 | Affinity Capture-MS | [4] | |||
| 3 | Affinity Capture-MS | [5] | |||
| Other proteins | [+] 2 Other proteins | + | |||
| Interacting Protein Name | UPF0606 protein KIAA1549 (KIAA1549) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [3] | |||
| 2 | Affinity Capture-MS | [4] | |||
| 3 | Affinity Capture-MS | [5] | |||
| Interacting Protein Name | Galectin-3-binding protein (LGALS3BP) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | 90K; BTBD17B; CyCAP; M2BP; MAC.2.BP; TANGO10B; gp90 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [3] | |||
| 2 | Affinity Capture-Western | [6] | |||
| 3 | Co-purification | [7] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. Proteomics. 2013 Nov;13(21):3131-44. | ||||
| REF 2 | Knockdown of GnT-Va expression inhibits ligand-induced downregulation of the epidermal growth factor receptor and intracellular signaling by inhibiting receptor endocytosis. Glycobiology. 2009 May;19(5):547-59. | ||||
| REF 3 | Characterization of LGALS3 (galectin-3) as a player in DNA damage response. Cancer Biol Ther. 2014 Jul;15(7):840-50. | ||||
| REF 4 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
| REF 5 | The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440. | ||||
| REF 6 | Mac-2-binding glycoproteins. Putative ligands for a cytosolic beta-galactoside lectin. J Biol Chem. 1991 Oct 5;266(28):18731-6. | ||||
| REF 7 | Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cystein... J Biol Chem. 1993 Jul 5;268(19):14245-9. | ||||
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