Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T71928 Target Info
Target Name MHC class I NK cell receptor 2DL1 (CD158A)
Synonyms p58.1 MHC class-I-specific NK receptor; p58 natural killer cell receptor clones CL-42/47.11; p58 NK receptor CL-42/47.11; Natural killer-associated transcript 1; NKAT1; NKAT-1; Killer cell immunoglobulin-like receptor 2DL1; CD158A; CD158 antigen-like family member A
Target Type Clinical trial Target
Gene Name KIR2DL1
Biochemical Class Immunoglobulin
UniProt ID
KI2L1_HUMAN 
Target Interacting Proteins  Top
Other proteins [+] 1 Other proteins +
Interacting Protein Name Major histocompatibility complex class I C (HLA-C) Interacting Protein Interacting Protein Info
UniProt ID
1C03_HUMAN 
Synonyms D6S204; HLA.JY3; HLC.C; PSORS1
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-crystal Structure [1]
2 Reconstituted Complex [2]
3 Reconstituted Complex [3]
References  Top
REF 1 Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. Nat Immunol. 2001 May;2(5):452-60.
REF 2 Disulfide bond-mediated dimerization of HLA-G on the cell surface. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16180-5.
REF 3 N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors. Hum Immunol. 2000 Dec;61(12):1202-18.

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