Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T71317 Target Info
Target Name AP-2 transcription factor (TFAP2A)
Synonyms Transcription factor AP-2-alpha; TFAP2; Activator protein 2; Activating enhancer-binding protein 2-alpha; AP2TF; AP2-alpha; AP-2
Target Type Literature-reported Target
Gene Name TFAP2A
UniProt ID
AP2A_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Yeast two hybrid [1]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Affinity Capture-Western [3]
3 Co-localization [2]
4 Reconstituted Complex [3]
5 Yeast two hybrid [2]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Reconstituted Complex [5]
Other proteins [+] 2 Other proteins +
Interacting Target Name Nucleophosmin (NPM1) Clinical trial Target Interacting Protein Info
UniProt ID
NPM_HUMAN 
Synonyms Numatrin; Nucleolar protein NO38; Nucleolar phosphoprotein B23; NPM
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Affinity Capture-Western [7]
3 Co-localization [6]
4 Reconstituted Complex [6]
5 Yeast two hybrid [7]
Interacting Protein Name Epsin-1 (EPN1) Interacting Protein Interacting Protein Info
UniProt ID
EPN1_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Reconstituted Complex [9]
References  Top
REF 1 Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2. J Biol Chem. 2003 May 2;278(18):16021-9.
REF 2 Tumor suppressor activity of AP2alpha mediated through a direct interaction with p53. J Biol Chem. 2002 Nov 22;277(47):45028-33.
REF 3 AP2alpha alters the transcriptional activity and stability of p53. Oncogene. 2006 Apr 6;25(15):2148-59.
REF 4 Modulation of IFN- receptor 1 expression by AP-2 influences IFN- sensitivity of cancer cells. Am J Pathol. 2012 Feb;180(2):661-71.
REF 5 Molecular basis of estrogen-induced cyclooxygenase type 1 upregulation in endothelial cells. Circ Res. 2005 Mar 18;96(5):518-25.
REF 6 Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation. EMBO Rep. 2007 Apr;8(4):394-400.
REF 7 Mutations in the SOD2 promoter reveal a molecular basis for an activating protein 2-dependent dysregulation of manganese superoxide dismutase expression in cancer cells. Mol Cancer Res. 2008 Dec;6(12):1881-93.
REF 8 Ubiquitin-interacting motifs of Epsin are involved in the regulation of insulin-dependent endocytosis. J Biochem. 2005 Mar;137(3):355-64.
REF 9 Epsin 1 is a polyubiquitin-selective clathrin-associated sorting protein. Traffic. 2006 Mar;7(3):262-81.

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