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| Target General Information |
Top |
| Target ID |
T71192 |
Target Info
|
| Target Name |
Leukotriene CysLT1 receptor (CYSLTR1) |
| Synonyms |
Leukotriene D4-receptor; LTD4 receptor; HMTMF81; HG55; G-protein coupled receptor HG55; Cysteinyl leukotriene receptor 1; Cysteinyl leukotriene D4 receptor; CysLTR1; CYSLT1 |
| Target Type |
Successful Target |
| Gene Name |
CYSLTR1 |
| Biochemical Class |
GPCR rhodopsin |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| G-protein-coupled receptors |
[+] 1 G-protein-coupled receptors |
+ |
| Interacting Target Name |
Leukotriene CysLT2 receptor (CYSLTR2) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
PSEC0146; HPN321; hGPCR21; G-protein coupled receptor HG57; Gprotein coupled receptor HG57; G-protein coupled receptor GPCR21; Gprotein coupled receptor GPCR21; Cysteinyl leukotriene receptor 2; CysLTR2; CYSLT2R; CYSLT2 |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Co-localization |
[2] |
| 3 |
Fluorescence Resonance Energy Transfer |
[1] |
| References |
Top |
| REF 1 |
CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. Blood. 2007 Nov 1;110(9):3263-70.
|
| REF 2 |
Ligand-induced tyrosine phosphorylation of cysteinyl leukotriene receptor 1 triggers internalization and signaling in intestinal epithelial cells. PLoS One. 2010 Dec 28;5(12):e14439.
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