Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T71023 Target Info
Target Name Synaptosomal-associated protein 25 (SNAP25)
Synonyms Synaptosomal-associated 25 kDa protein; Super protein; SUP; SNAP-25; SNAP
Target Type Successful Target
Gene Name SNAP25
Biochemical Class Synaptosomal vesicle fusion pore
UniProt ID
SNP25_HUMAN 
Target Interacting Proteins  Top
Vesicle fusion pores [+] 1 Vesicle fusion pores +
Interacting Protein Name Syntaxin-1A (STX1A) Interacting Protein Interacting Protein Info
UniProt ID
STX1A_HUMAN 
Synonyms HPC.1; P35.1; STX1; SYN1A
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Reconstituted Complex [4]
5 Yeast two hybrid [5]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Vesicle-associated membrane protein 2 (VAMP2) Interacting Protein Interacting Protein Info
UniProt ID
VAMP2_HUMAN 
Synonyms SYB2; VAMP.2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Affinity Capture-Western [6]
3 Co-crystal Structure [7]
4 Reconstituted Complex [8]
References  Top
REF 1 Snapin: a SNARE-associated protein implicated in synaptic transmission. Nat Neurosci. 1999 Feb;2(2):119-24.
REF 2 Spring, a novel RING finger protein that regulates synaptic vesicle exocytosis. J Biol Chem. 2001 Nov 2;276(44):40824-33.
REF 3 Alpha-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis. EMBO Rep. 2010 Jul;11(7):528-33.
REF 4 SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils. J Biol Chem. 1994 Nov 4;269(44):27427-32.
REF 5 A human protein-protein interaction network: a resource for annotating the proteome. Cell. 2005 Sep 23;122(6):957-68.
REF 6 E3 ubiquitin ligase RNF13 involves spatial learning and assembly of the SNARE complex. Cell Mol Life Sci. 2013 Jan;70(1):153-65.
REF 7 Three-dimensional structure of the complexin/SNARE complex. Neuron. 2002 Jan 31;33(3):397-409.
REF 8 Effect of mutations in vesicle-associated membrane protein (VAMP) on the assembly of multimeric protein complexes. J Neurosci. 1997 Mar 1;17(5):1596-603.

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