Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T70851 Target Info
Target Name Extracellular signal-regulated kinase 5 (ERK5)
Synonyms PRKM7; Mitogen-activated protein kinase 7; MAPK 7; MAP kinase 7; ERK-5; Big MAP kinase 1; BMK1; BMK-1
Target Type Patented-recorded Target
Gene Name MAPK7
Biochemical Class Kinase
UniProt ID
MK07_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 1 Kinases +
Interacting Target Name ERK activator kinase 5 (MAP2K5) Literature-reported Target Interacting Protein Info
UniProt ID
MP2K5_HUMAN 
Synonyms PRKMK5; MKK5; Mitogen-activatedprotein kinase kinase 5; MEK5; MEK 5; MAPKK 5; MAPK/ERK kinase 5; MAP kinase kinase5; MAP kinase kinase 5; Dual specificity mitogen-activated protein kinase kinase 5
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [2]
3 Reconstituted Complex [3]
4 Yeast two hybrid [3]
Proteins 14-3-3 [+] 1 Proteins 14-3-3 +
Interacting Protein Name 14-3-3 protein epsilon (YWHAE) Interacting Protein Interacting Protein Info
UniProt ID
1433E_HUMAN 
Synonyms 14.3.3E; HEL2; KCIP.1; MDCR; MDS
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Yeast two hybrid [5]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Promyelocytic leukemia protein (PML) Interacting Protein Interacting Protein Info
UniProt ID
PML_HUMAN 
Synonyms MYL; PP8675; RNF71; TRIM19
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Affinity Capture-Western [7]
3 Reconstituted Complex [7]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J. 2014 Aug 18;33(16):1784-801.
REF 3 Components of a new human protein kinase signal transduction pathway. J Biol Chem. 1995 May 26;270(21):12665-9.
REF 4 Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex. Mol Cell Biol. 2013 Apr;33(8):1671-86.
REF 5 14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function. J Biol Chem. 2004 Mar 5;279(10):8787-91.
REF 6 Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell. 2010 Sep 14;18(3):258-67.
REF 7 BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction. Oncogene. 2013 Jun 27;32(26):3156-64.

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