Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T68251 | Target Info | |||
| Target Name | Matrix metalloproteinase-2 (MMP-2) | ||||
| Synonyms | TBE-1; Matrix metalloproteinase 2; CLG4A; 72 kDa type IV collagenase; 72 kDa gelatinase | ||||
| Target Type | Successful Target | ||||
| Gene Name | MMP2 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Growth factors | [+] 1 Growth factors | + | |||
| Interacting Target Name | Transforming growth factor beta 1 (TGFB1) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1; TGF-beta1; TGF-beta 1; TGFB | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Biochemical Activity | [1] | |||
| 2 | Co-localization | [2] | |||
| Other proteins | [+] 3 Other proteins | + | |||
| Interacting Protein Name | Metalloproteinase inhibitor 2 (TIMP2) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | CSC.21K; DDC8; KIAA1731NL | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [3] | |||
| 2 | Co-crystal Structure | [4] | |||
| 3 | Reconstituted Complex | [5] | |||
| Interacting Protein Name | Alpha-2-macroglobulin (A2M) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | A2MD; CPAMD5; FWP007; S863.7 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Co-localization | [2] | |||
| 2 | Reconstituted Complex | [6] | |||
| Interacting Protein Name | Metalloproteinase inhibitor 3 (TIMP3) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | HSMRK222; K222; K222TA2; SFD | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [3] | |||
| 2 | Reconstituted Complex | [7] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev. 2000 Jan 15;14(2):163-76. | ||||
| REF 2 | Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46. | ||||
| REF 3 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
| REF 4 | Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7414-9. | ||||
| REF 5 | Utilization of a novel recombinant myoglobin fusion protein expression system to characterize the tissue inhibitor of metalloproteinase (TIMP)-4 and TIMP-2 C-terminal domain and tails by mutagenesis. The importance of acidic residues in binding the MMP-2 hemopexin C-domain. J Biol Chem. 2002 Dec 13;277(50):48696-707. | ||||
| REF 6 | Interaction of matrix metalloproteinases-2 and -9 with pregnancy zone protein and alpha2-macroglobulin. Arch Biochem Biophys. 1997 Nov 1;347(1):62-8. | ||||
| REF 7 | Human tissue inhibitor of metalloproteinases 3 interacts with both the N- and C-terminal domains of gelatinases A and B. Regulation by polyanions. J Biol Chem. 1999 Apr 16;274(16):10846-51. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.