Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T68211 | Target Info | |||
| Target Name | High mobility group protein HMG-I/Y (HMGA1) | ||||
| Synonyms | High mobility group protein R; High mobility group protein HMG-I/HMG-Y; High mobility group protein A1; High mobility group AT-hook protein 1; HMGIY; HMG-I(Y) | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | HMGA1 | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Kinases | [+] 1 Kinases | + | |||
| Interacting Target Name | Casein kinase II alpha (CSNK2A1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Protein kinase CK2; CK2A1; CK II alpha; CK II; Casein kinase II subunit alpha | ||||
| Evidence Score (E-score) | 1 Experimental Evidences | + | |||
| 1 | Biochemical Activity | [1] | |||
| Nuclear hormone receptors | [+] 1 Nuclear hormone receptors | + | |||
| Interacting Target Name | Peroxisome proliferator-activated receptor gamma (PPAR-gamma) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Transcription factor PPAR gamma receptor; PPAR-gamma; PPARgamma; Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Reconstituted Complex | [2] | |||
| 2 | Yeast two hybrid | [3] | |||
| Transcription regulators | [+] 2 Transcription regulators | + | |||
| Interacting Target Name | Transcription factor Sp1 (SP1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | TSFP1 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [4] | |||
| 2 | Affinity Capture-Western | [5] | |||
| 3 | Reconstituted Complex | [4] | |||
| Interacting Target Name | CREB-binding protein (CREBBP) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | CREBbinding protein; CBP | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Biochemical Activity | [6] | |||
| 2 | Yeast two hybrid | [3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A bead-based approach for large-scale identification of in vitro kinase substrates. Proteomics. 2011 Dec;11(24):4632-7. | ||||
| REF 2 | The insulin receptor: a new anticancer target for peroxisome proliferator-activated receptor-gamma (PPARgamma) and thiazolidinedione-PPARgamma agonists. Endocr Relat Cancer. 2008 Mar;15(1):325-35. | ||||
| REF 3 | Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor. J Biol Chem. 1999 Aug 6;274(32):22563-8. | ||||
| REF 4 | A nucleoprotein complex containing Sp1, C/EBP beta, and HMGI-Y controls human insulin receptor gene transcription. Mol Cell Biol. 2003 Apr;23(8):2720-32. | ||||
| REF 5 | HMGA1 protein is a positive regulator of the insulin-like growth factor-I receptor gene. Eur J Cancer. 2010 Jul;46(10):1919-26. | ||||
| REF 6 | Acetylation of HMG I(Y) by CBP turns off IFN beta expression by disrupting the enhanceosome. Mol Cell. 1998 Oct;2(4):457-67. | ||||
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