Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T67416 Target Info
Target Name Bifunctional aminoacyl-tRNA synthetase (EPRS)
Synonyms QPRS; QARS; ProlinetRNA ligase; PIG32; GlutamatylprolyltRNA synthetase; Glutamatyl-prolyl-tRNA synthetase; GluRS; EPRS; Cell proliferationinducing gene 32 protein; Cell proliferation-inducing gene 32 protein; Bifunctional glutamate/prolinetRNA ligase; Bifunctional glutamate/proline--tRNA ligase; Bifunctional aminoacyltRNA synthetase
Target Type Clinical trial Target
Gene Name EPRS
Biochemical Class Carbon-oxygen ligase
UniProt ID
SYEP_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 1 Kinases +
Interacting Protein Name Lysine--tRNA ligase (KARS) Interacting Protein Interacting Protein Info
UniProt ID
SYK_HUMAN 
Synonyms CMTRIB; DFNB89; KARS1; KARS2; KRS
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-fractionation [2]
Ligases [+] 2 Ligases +
Interacting Target Name Isoleucyl-tRNA synthetase (IARS) Literature-reported Target Interacting Protein Info
UniProt ID
SYIC_HUMAN 
Synonyms Isoleucine--tRNA ligase, cytoplasmic; Isoleucine--tRNA ligase; IRS; IleRS
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Co-fractionation [4]
3 Co-fractionation [2]
4 Reconstituted Complex [3]
5 Yeast two hybrid [3]
Interacting Protein Name Arginyl-tRNA synthetase (RARS) Interacting Protein Interacting Protein Info
UniProt ID
SYRC_HUMAN 
Synonyms ArgRS; DALRD1
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-fractionation [2]
2 Yeast two hybrid [3]
References  Top
REF 1 Interaction of two translational components, lysyl-tRNA synthetase and p40/37LRP, in plasma membrane promotes laminin-dependent cell migration. FASEB J. 2012 Oct;26(10):4142-59.
REF 2 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 3 A multifunctional repeated motif is present in human bifunctional tRNA synthetase. J Biol Chem. 1998 May 1;273(18):11267-73.
REF 4 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.

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