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| Target General Information |
Top |
| Target ID |
T66665 |
Target Info
|
| Target Name |
Prostaglandin G/H synthase 2 (COX-2) |
| Synonyms |
Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PHS II; PGHS-2; PGH synthase 2; Cyclooxygenase-2; COX2; COX-2 |
| Target Type |
Successful Target |
| Gene Name |
PTGS2 |
| Biochemical Class |
Paired donor oxygen oxidoreductase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Auxiliary transporters |
[+] 1 Auxiliary transporters |
+ |
| Interacting Target Name |
Caveolin 1 (CAV1) |
Literature-reported Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Caveolin-1; Caveolin1; Cav-1; CAV |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Co-fractionation |
[1] |
| 3 |
Reconstituted Complex |
[1] |
| Pore-forming toxins |
[+] 1 Pore-forming toxins |
+ |
| Interacting Target Name |
Cellular tumor antigen p53 (TP53) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13 |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[2] |
| 2 |
Co-purification |
[3] |
| 3 |
Reconstituted Complex |
[3] |
| References |
Top |
| REF 1 |
Colocalization and interaction of cyclooxygenase-2 with caveolin-1 in human fibroblasts. J Biol Chem. 2001 Sep 14;276(37):34975-82.
|
| REF 2 |
COX-2 regulates p53 activity and inhibits DNA damage-induced apoptosis. Biochem Biophys Res Commun. 2005 Mar 25;328(4):1107-12.
|
| REF 3 |
Cyclooxygenase-2 functionally inactivates p53 through a physical interaction with p53. Biochim Biophys Acta. 2009 Aug;1793(8):1354-65.
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