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| Target General Information |
Top |
| Target ID |
T65198 |
Target Info
|
| Target Name |
Pro-neuregulin-1 (Pro-NRG1) |
| Synonyms |
SMDF (20-241); Pro-neuregulin-1, membrane-bound isoform (20-241); NDF (20-241); Heregulin (20-241); HRGA (20-241); HGL (20-241); GGF (20-241) |
| Target Type |
Clinical trial Target |
| Gene Name |
NRG1 |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Kinases |
[+] 1 Kinases |
+ |
| Interacting Target Name |
Epidermal growth factor receptor (EGFR) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Protein-Fragment Complementation Assay |
[2] |
| 3 |
Yeast two hybrid |
[3] |
| References |
Top |
| REF 1 |
Neu differentiation factor inhibits EGF binding. A model for trans-regulation within the ErbB family of receptor tyrosine kinases. J Biol Chem. 1995 Apr 28;270(17):9982-90.
|
| REF 2 |
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
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| REF 3 |
In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
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