Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T65084 Target Info
Target Name Ubiquitin thioesterase OTU1 (YOD1)
Synonyms PRO0907; OTUD2; OTU domain-containing protein 2; HsHIN7; HIV-1-induced protease 7; HIN7; HIN-7; DUBA8; DUBA-8
Target Type Literature-reported Target
Gene Name YOD1
Biochemical Class Peptidase
UniProt ID
OTU1_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Target Name Valosin-containing protein p97 (VCP) Clinical trial Target Interacting Protein Info
UniProt ID
TERA_HUMAN 
Synonyms Valosin-containing protein; Transitional endoplasmic reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 subunit
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Affinity Capture-Western [2]
4 Reconstituted Complex [1]
5 Reconstituted Complex [3]
6 Yeast two hybrid [3]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 5 Experimental Evidences +
1 Biochemical Activity [4]
2 Biochemical Activity [5]
3 Biochemical Activity [1]
4 Co-crystal Structure [4]
5 Reconstituted Complex [1]
References  Top
REF 1 The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Mol Cell. 2009 Oct 9;36(1):28-38.
REF 2 Lys11- and Lys48-linked ubiquitin chains interact with p97 during endoplasmic-reticulum-associated degradation. Biochem J. 2014 Apr 1;459(1):205-16.
REF 3 YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-B. Elife. 2017 Feb 28;6. pii: e22416.
REF 4 OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell. 2013 Jul 3;154(1):169-84.
REF 5 Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets. Cell Chem Biol. 2016 Apr 21;23(4):472-82.

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